Evidence map›Paper›PMID 31983159›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Association between SNPs and Loss of Methylation Site on the CpG island of the Promoter Region of the Smoothened Gene, Potential Molecular Markers for Susceptibility to the Development of Basal Cell Carcinoma in the Brazilian Population.

Augusto Monteiro de Souza, Otávio Sérgio Lopes, Andressa de Lima Liberato, Paulo Junior Ribeiro de Oliveira, Sylvia Satomi Takeno Herrero, Agnaldo Luiz do Nascimento, Carlos Alberto Longui, Ivan Rodrigues de Carvalho Filho, Leonardo Ferreira Soares, Renally Barbosa da Silva and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Augusto Monteiro de SouzaLaboratory of Structural Molecular Biology and Oncogenetics - LBMEO, Federal University of Paraiba, João Pessoa - PB, Brazil.ORCID 0000-0002-6269-5536
Otávio Sérgio LopesDepartment of Dermatology, Dermatological Clinic Santa Catarina, João Pessoa - PB - Brazil.
Andressa de Lima LiberatoLaboratory of Structural Molecular Biology and Oncogenetics - LBMEO, Federal University of Paraiba, João Pessoa - PB, Brazil.
Paulo Junior Ribeiro de OliveiraLaboratory of Structural Molecular Biology and Oncogenetics - LBMEO, Federal University of Paraiba, João Pessoa - PB, Brazil.
Sylvia Satomi Takeno HerreroLaboratory of Structural Molecular Biology and Oncogenetics - LBMEO, Federal University of Paraiba, João Pessoa - PB, Brazil.
Agnaldo Luiz do NascimentoLaboratory of Structural Molecular Biology and Oncogenetics - LBMEO, Federal University of Paraiba, João Pessoa - PB, Brazil.
Carlos Alberto LonguiPostgraduate Program in Health Sciences; Santa Casa School of Medical Sciences of São Paulo; Sao Paulo - SP, Brazil.
Ivan Rodrigues de Carvalho FilhoDepathology of Pathology, Laboratory of Medical Analysis - UNILAB, João Pessoa - PB, Brazil.
Leonardo Ferreira Soares6Pharmacy Department; State University of Paraíba; Campina Grande - PB, Brazil.
Renally Barbosa da SilvaPostgraduate Program in Natural Sciences and Biotechnology, Federal University of Campina Grande - UFCG, Campus de Cuité - PB, Brazil.
Rommel Rodriguez BurbanoInstitute of Biological Sciences; Federal University of Pará; Belém - PA - Brazil Brazil.
Plínio DelatorreLaboratory of Structural Molecular Biology and Oncogenetics - LBMEO, Federal University of Paraiba, João Pessoa - PB, Brazil.
Eleonidas Moura LimaLaboratory of Structural Molecular Biology and Oncogenetics - LBMEO, Federal University of Paraiba, João Pessoa - PB, Brazil.ORCID 0000-0002-8504-3514
Faculdade de Ciências Médicas da Santa Casa de São Paulo · BRUniversidade Federal da Paraíba · BRUniversidade Estadual da Paraíba · BRUniversidade Federal do Pará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePerform genotyping of SNPs in the promoter region of the SMO gene in BCC samples from patients from northeastern Brazil, and to determine if there is an association of these SNPs of the gene in question with the susceptibility to the development of the BCC.

methods100 samples of paraffined tissue from patients with histopathological diagnosis of BCC and 100 control samples were analyzed for each polymorphism by a newly developed genotyping method, the Dideoxy Single Allele Specific - PCR. The software Bioestat - version 5.3 and Haploview 4.2 were used for the statistical analysis. For all tests a P-value.

Indexed as

AllelesBasal Cell CarcinomaBiomarkers, TumorBrazilCpG IslandsDNA MethylationGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotidePromoter Regions, GeneticRetrospective StudiesSkin NeoplasmsSmoothened ReceptorBiomarkers, TumorSmoothened ReceptorSMO protein, humanBasal cell carcinomaCpG-SNPsmolecular markers e DSAPSvia Hedgehog

Identifiers

PMID31983159
PMCPMC7294008
OpenAlexW3003591643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.