ArticleJournal of cellular and molecular medicine2020
Spatial relationship between telocytes, interstitial cells of Cajal and the enteric nervous system in the human ileum and colon.
Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Variations in the Density and Distribution of Cajal Like Cells Associated With the Pathogenesis of Ureteropelvic Junction Obstruction: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2021Pooled it
- Pathology Seen in Myenteric Plexus in Two Subjects With Waardenburg Syndrome.Neurogastroenterology and motility · 2025Article
- Telocytes: history, origin, identification, structure, distribution, and functions.Histochemistry and cell biology · 2025Review
- Volumetric changes of the enteric nervous system under physiological and pathological conditions measured using x-ray phase-contrast tomography.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- The transition zone in Hirschsprung's bowel contains abnormal hybrid ganglia with characteristics of extrinsic nerves.Journal of cellular and molecular medicine · 2023Article
- Structure of the myenteric plexus in normal and diseased human ileum analyzed by X-ray virtual histology slices.World journal of gastroenterology · 2022Article
- A possible association between early life factors and burden of functional bowel symptoms in adulthood.Scandinavian journal of primary health care · 2021Article
- Telocytes: An Emerging Component of Stem Cell Niche Microenvironment.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Review
- Idiopathic Megacolon-Short Review.Diagnostics (Basel, Switzerland) · 2021Review
- Cardiac Telocytes 16 Years on-What Have We Learned So Far, and How Close Are We to Routine Application of the Knowledge in Cardiovascular Regenerative Medicine?International journal of molecular sciences · 2021Review
- Telocytes promote hepatocellular carcinoma by activating the ERK signaling pathway and miR-942-3p/MMP9 axis.Cell death discovery · 2021Article
- The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson's Disease.Life (Basel, Switzerland) · 2021Review
- 3d phase-contrast nanotomography of unstained human skin biopsies may identify morphological differences in the dermis and epidermis between subjects.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2021Article
- Impairment in the telocyte/CD34Journal of cellular and molecular medicine · 2021Article
- Review
- Telocytes/CD34+ Stromal Cells in Pathologically Affected White Adipose Tissue.International journal of molecular sciences · 2020Review
- Morphological and immunohistochemical phenotype of TCs in the intestinal bulb of Grass carp and their potential role in intestinal immunity.Scientific reports · 2020Article
- Telocytes in the Normal and Pathological Peripheral Nervous System.International journal of molecular sciences · 2020Review
- Spatial relationship between telocytes, interstitial cells of Cajal and the enteric nervous system in the human ileum and colon.Journal of cellular and molecular medicine · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telocytes (TCs) are recently described interstitial cells, present in almost all human organs. Among many other functions, TCs regulate gastrointestinal motility together with the interstitial cells of Cajal (ICCs). TCs and ICCs have close localization in the human myenteric plexus; however, the exact spatial relationship cannot be clearly examined by previously applied double immunofluorescence/confocal microscopy. Data on TCs and submucosal ganglia and their relationship to intestinal nerves are scarce. The aim of the study was to analyse the spatial relationship among these components in the normal human ileum and colon with double CD34/CD117 and CD34/S100 immunohistochemistry and high-resolution light microscopy. TCs were found to almost completely encompass both myenteric and submucosal ganglia in ileum and colon. An incomplete monolayer of ICCs was localized between the TCs and the longitudinal muscle cells in ileum, whereas only scattered ICCs were present on both surfaces of the colonic myenteric ganglia. TC-telopodes were observed within colonic myenteric ganglia. TCs, but no ICCs, were present within and around the interganglionic nerve fascicles, submucosal nerves and mesenterial nerves, but were only observed along small nerves intramuscularly. These anatomic differences probably reflect the various roles of TCs and ICCs in the bowel function.
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