Evidence map›Paper›PMID 31983040›Full record

ArticleJournal of endocrinological investigation2020

Metabolic syndrome is the key determinant of impaired vaginal lubrication in women with chronic spinal cord injury.

S D'Andrea, C Castellini, V Paladino, M Totaro, G Felzani, S Francavilla, F Francavilla, A Barbonetti

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Article in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

S D'AndreaAndrology Unit, Department of Life, Health and Environment Sciences, University of L'Aquila, Piazzale Tommasi 1, 67110, L'Aquila, Italy.
C CastelliniAndrology Unit, Department of Life, Health and Environment Sciences, University of L'Aquila, Piazzale Tommasi 1, 67110, L'Aquila, Italy.
V PaladinoAndrology Unit, Department of Life, Health and Environment Sciences, University of L'Aquila, Piazzale Tommasi 1, 67110, L'Aquila, Italy.
M TotaroAndrology Unit, Department of Life, Health and Environment Sciences, University of L'Aquila, Piazzale Tommasi 1, 67110, L'Aquila, Italy.
G FelzaniSpinal Unit, San Raffaele Institute of Sulmona, Sulmona, Italy.
S FrancavillaAndrology Unit, Department of Life, Health and Environment Sciences, University of L'Aquila, Piazzale Tommasi 1, 67110, L'Aquila, Italy.
F FrancavillaAndrology Unit, Department of Life, Health and Environment Sciences, University of L'Aquila, Piazzale Tommasi 1, 67110, L'Aquila, Italy.
A BarbonettiAndrology Unit, Department of Life, Health and Environment Sciences, University of L'Aquila, Piazzale Tommasi 1, 67110, L'Aquila, Italy. arcangelo.barbonetti@univaq.it.ORCID http://orcid.org/0000-0002-6888-9585
University of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSpinal cord injury (SCI) affects sexual health of both male and female, but little attention has been given to sexuality of SCI women. Similar to penile erection, vaginal lubrication represents a neurovascular event and then both denervation and vascular damage might contribute to its impairment. Nevertheless, the relative weight of lesion location/degree and vascular risk factors in determining hypolubrication in women with SCI has not yet been investigated. The aim of this study was to recognize among putative determinants of poor sexual arousal in women with SCI, neurogenic and vascular/metabolic independent predictors of vaginal hypolubrication.

methodsTwenty-eight consecutive female patients admitted to a rehabilitation program because of chronic SCI (≥ 1 year) underwent clinical and biochemical evaluations, including assessment of vaginal lubrication by the Female Sexual Function Index (FSFI). As, in people with SCI, waist circumference overestimates visceral fat mass due to abdominal muscle paralysis, metabolic syndrome (MetS) was defined according to specific criteria proposed for SCI population: BMI ≥ 22 kg/m

resultsA FSFI lubrication sub-score < 3.6, suggestive for impaired vaginal lubrication, was exhibited by 53.7% of the study population. When compared to the group with normal lubrication, a significantly higher proportion of these women had paraplegia (93.3% vs 38.5%, p = 0.003) and met the SCI-specific criteria for MetS (73.4% vs 7.6%, p = 0.0006), whereas, no significant differences were found between the two groups in the proportion of women exhibiting the single components of MetS. At the multiple logistic regression analysis, only the presence of MetS exhibited a significant independent association with impaired vaginal lubrication (OR = 3.1, 95% CI 1.2, 5.8, p = 0.01).

conclusionsIn women with SCI, a clustering of modifiable vascular/metabolic risk factors, constituting the MetS, could contribute to sexual dysfunctions by affecting the vaginal lubrication, independently of the level of the spinal cord lesion.

Indexed as

AdultBody FluidsFemaleHumansItalyMetabolic SyndromeMiddle AgedPrognosisRisk FactorsSexual Dysfunction, PhysiologicalSexualitySpinal Cord InjuriesSurveys and QuestionnairesVaginaVaginal DiseasesFemale sexual dysfunctionFemale sexual functioningMetabolic syndromeSpinal cord injuryVaginal lubrication

Identifiers

PMID31983040
OpenAlexW3001305238

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.