Evidence map›Paper›PMID 31983034›Full record

ArticleJournal of bone and mineral metabolism2020

Oral contraceptive use, bone mineral density, and bone turnover markers over 12 months in college-aged females.

Hawley C Almstedt, Makenzie M Cook, Lily F Bramble, Deepa V Dabir, Joseph W LaBrie

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Primary Ovarian Insufficiency, Bone Health, and Other Outcomes in Adolescents.Obstetrics and gynecology clinics of North America · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Epidemiological Survey on the Perception of Adverse Effects in Women Using Contraceptive Methods in Brazil.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022
    Article
  11. Review
  12. EFFECT OF ORAL CONTRACEPTIVES ON BONE MINERAL DENSITY.Acta endocrinologica (Bucharest, Romania : 2005)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hawley C AlmstedtHuman Performance Laboratory, Department of Health and Human Sciences, Loyola Marymount University, 1 LMU Drive MS 8888, Los Angeles, CA, 90045, USA. Hawley.almstedt@lmu.edu.ORCID http://orcid.org/0000-0002-4310-2424
Makenzie M CookHuman Performance Laboratory, Department of Health and Human Sciences, Loyola Marymount University, 1 LMU Drive MS 8888, Los Angeles, CA, 90045, USA.
Lily F BrambleHuman Performance Laboratory, Department of Health and Human Sciences, Loyola Marymount University, 1 LMU Drive MS 8888, Los Angeles, CA, 90045, USA.
Deepa V DabirDepartment of Biology, Loyola Marymount University, 1 LMU Drive MS 8888, Los Angeles, CA, 90045, USA.
Joseph W LaBrieHeadsUp Laboratory, Department of Psychology, Loyola Marymount University, 1 LMU Drive Suite 4700, Los Angeles, CA, 90045, USA.
Loyola Marymount University · US

Funding

Alcohol and Bone Health: Skeletal Effects of Heavy Episodic Drinking in CollegeSignificanceR21AA022942 · NIAAA · LOYOLA MARYMOUNT UNIVERSITY · PI ALMSTEDT, HAWLEY CHASE, LABRIE, JOSEPH W. · 2015 to 2016
$362k
NIAAA NIH HHS R21 AA022942NIAAA NIH HHS R21AA022942
6 · The paper itself

Abstract

introductionThe purpose of this study was to compare bone mineral density (BMD) and bone turnover markers between combined oral contraceptive (COC) and non-COC users over 12 months. MATERIALS AND

methodsCOC users (n = 34, age = 19.2 ± 0.5) and non-COC users (n = 28, age = 19.3 ± 0.6) provided serum at baseline, 6 months, and 12 months. C-terminal telopepetides (CTX) and pro-collagen type 1 N-terminal propeptides (P1NP) were determined using ELISA. BMD was measured at the three time points using dual-energy x-ray absorptiometry (DXA).

resultsCOC users had greater CTX than non-COC users at baseline (18.6 ± 8.2 vs. 13.8 ± 5.3 ng/mL, P = 0.021) and 6 months (20.4 ± 10.3 vs. 14.2 ± 8.5 ng/mL, P = 0.018). Controlling for lean mass, groups were similar in BMD. Over 12 months, non-COC users maintained BMD at the spine, while the COC users declined 2.2% in lateral spine BMD (0.773 ± 0.014 to 0.756 ± 0.014 g/cm

conclusionCollege-aged women who did not use COCs increased BMD of the whole body, while COC users had elevated bone turnover, declines in spinal BMD, and lack of bone acquisition of the whole body over 12 months. Young females who initiate COC use early after menarche may experience skeletal detriments.

Indexed as

Absorptiometry, PhotonBiomarkersBone DensityBone RemodelingContraceptives, Oral, CombinedEthinyl EstradiolFemaleHumansSpineYoung AdultBiomarkersContraceptives, Oral, CombinedEthinyl EstradiolCTXMenarcheP1NPPeak bone massPremenopausal

Identifiers

PMID31983034
PMCPMC10317246
OpenAlexW3000858250

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.