ArticleDigestive diseases and sciences2020
Neurocognitive and Muscular Capacities Are Associated with Frailty in Adults with Cirrhosis.
Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- ReacStick: Evaluating Executive Function Independent From Level of Education.American journal of physical medicine & rehabilitation · 2026Article
- Clinical estimates of three physiologic capacities explain a majority of unipedal stance time.Aging clinical and experimental research · 2025Article
- Integrative Hepatology: Enhancing overall health to manage liver disease.Hepatology (Baltimore, Md.) · 2025Article
- Executive function is associated with balance and falls in older cancer survivors treated with chemotherapy: A cross-sectional study.Journal of geriatric oncology · 2023Article
- Falls are an underappreciated driver of morbidity and mortality in cirrhosis.Clinical liver disease · 2022Review
- Liver Frailty Index for Prediction of Short-Term Rehospitalization in Patients with Liver Cirrhosis.Diagnostics (Basel, Switzerland) · 2022Article
- Cognitive Impairment and Physical Frailty in Patients With Cirrhosis.Hepatology communications · 2022Article
- Falls are Common, Morbid, and Predictable among People with Cirrhosis.European journal of gastroenterology & hepatology · 2021Article
- Cognitive Function, Sarcopenia, and Inflammation Are Strongly Associated with Frailty: A Framingham Cohort Study.The American journal of medicine · 2021Article
- Falls are common, morbid, and predictable in patients with cirrhosis.Journal of hepatology · 2021Article
- Article
- Incidence and Bedside Predictors of the First Episode of Overt Hepatic Encephalopathy in Patients With Cirrhosis.The American journal of gastroenterology · 2020Article
- Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy.Journal of clinical medicine · 2020Article
- Frailty in Rheumatic Diseases.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFrailty is common in cirrhosis and associated with mortality, hospitalization, and reduced quality of life. Interventions aimed at forestalling frailty are limited by a lack of understanding of underlying physiologic deficits.
aimsThis study's aim was to examine contributions of discrete sensorimotor and neurocognitive capacities to conventional frailty measures of unipedal stance time, chair stands, and grip strength.
methodsThis cross-sectional study enrolled 119 outpatients with cirrhosis (50% female, aged 62.9 ± 7.3 years). Capacities included sensory (lower limb sensation and visual contrast), neurocognitive (Number Connection Tests A and B, simple and recognition reaction time), and muscular (hip/core strength determined by lateral plank time (LPT)). Bivariate analyses and linear regression models were performed to identify significant contributors to each frailty measure.
resultsThe average performance was 9.8 ± 3.9 chair stands, 12.7 s ±9.9 unipedal stance time, and 60.3 ± 25.6 lb grip strength. In multivariate models, factors explained 40% of variance in unipedal stance and 43% of variance in chair stands. The LPT was most strongly associated with unipedal stance and chair stands. Grip strength was associated with LPT, but did not have physiologic predictors.
conclusionsClinically useful measures of frailty in adults with cirrhosis can be explained by disease severity but also deficits in strength and neurocognitive function. Recognition reaction time, a novel measure in cirrhosis, had a significant contribution to frailty. These findings have implications for frailty assessment and suggest that the optimal rehabilitation approach to frailty targets neurocognitive function in addition to strengthening.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.