Evidence map›Paper›PMID 31982991›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

A kinetics-based approach to amyloid PET semi-quantification.

A Chincarini, E Peira, M Corosu, S Morbelli, M Bauckneht, S Capitanio, M Pardini, D Arnaldi, C Vellani, D D'Ambrosio and 7 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Amyloid PET Imaging: Standard Procedures and Semiquantification.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  4. A comparison of advanced semi-quantitative amyloid PET analysis methods.European journal of nuclear medicine and molecular imaging · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

A ChincariniIstituto Nazionale di Fisica Nucleare (INFN), via Dodecaneso 33, I-16146, Genova, Italy. andrea.chincarini@ge.infn.it.ORCID 0000-0003-4094-9942
E PeiraIstituto Nazionale di Fisica Nucleare (INFN), via Dodecaneso 33, I-16146, Genova, Italy.
M CorosuIstituto Nazionale di Fisica Nucleare (INFN), via Dodecaneso 33, I-16146, Genova, Italy.
S MorbelliNuclear Medicine Unit (DISSAL), University of Genoa, Genova, Italy.
M BaucknehtNuclear Medicine Unit (DISSAL), University of Genoa, Genova, Italy.
S CapitanioNuclear Medicine Unit (DISSAL), University of Genoa, Genova, Italy.
M PardiniDept. of Neuroscience, Rehabilitation ,Ophthalmology, Genetics, Child and Maternal Health (DINOGMI), University of Genoa, Genova, Italy.
D ArnaldiDept. of Neuroscience, Rehabilitation ,Ophthalmology, Genetics, Child and Maternal Health (DINOGMI), University of Genoa, Genova, Italy.
C VellaniNuclear Medicine Unit of Pavia Institute, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.
D D'AmbrosioMedical Physics Unit of Pavia Institute, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.
V GaribottoFaculty of Medicine, University of Geneva, Geneva, Switzerland.
F AssalFaculty of Medicine, University of Geneva, Geneva, Switzerland.
B PagheraNuclear Medicine Unit, ASST Spedali Civili, Brescia, Italy.
G SavelliNuclear Medicine Unit, Fondazione Poliambulanza, Brescia, Italy.
A StefanelliNuclear Medicine Unit, Fondazione Poliambulanza, Brescia, Italy.
U P GuerraNuclear Medicine Unit, Fondazione Poliambulanza, Brescia, Italy.
F NobiliDept. of Neuroscience, Rehabilitation ,Ophthalmology, Genetics, Child and Maternal Health (DINOGMI), University of Genoa, Genova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo develop and validate a semi-quantification method (time-delayed ratio, TDr) applied to amyloid PET scans, based on tracer kinetics information.

methodsThe TDr method requires two static scans per subject: one early (~ 0-10 min after the injection) and one late (typically 50-70 min or 90-100 min after the injection, depending on the tracer). High perfusion regions are delineated on the early scan and applied onto the late scan. A SUVr-like ratio is calculated between the average intensities in the high perfusion regions and the late scan hotspot. TDr was applied to a naturalistic multicenter dataset of 143 subjects acquired with [

resultsTDr shows excellent agreement with respect to the binary visual assessment (AUC = 0.99) and significantly correlates with both validated semi-quantification methods, reaching a Pearson correlation coefficient of 0.86 with respect to ELBA.

conclusionsTDr is an alternative approach to previously validated ones (SUVr and ELBA). It requires minimal image processing; it is independent on predefined regions of interest and does not require MR registration. Besides, it takes advantage on the availability of early scans which are becoming common practice while imposing a negligible added patient discomfort.

Indexed as

Alzheimer DiseaseAmyloidosisAmyloidAniline CompoundsBrainHumansKineticsPositron-Emission TomographyAmyloidAniline CompoundsAmyloid PETFluorinated tracerSemi-quantificationTracer kinetics

Identifiers

PMID31982991

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.