Evidence map›Paper›PMID 31982426›Full record

ArticleJournal of molecular and cellular cardiology2020

Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.

Qinghua Hu, Azmi A Ahmad, Thomas Seidel, Chris Hunter, Molly Streiff, Linda Nikolova, Kenneth W Spitzer, Frank B Sachse

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. The odyssey of the TR(i)P journey to the cellular membrane.Frontiers in cell and developmental biology · 2024
    Review
  4. The Dysfunction of CaInternational journal of molecular sciences · 2023
    Review
  5. Effects of Sarcolemmal Background CaFrontiers in physiology · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Calcium and Heart Failure: How Did We Get Here and Where Are We Going?International journal of molecular sciences · 2021
    Review
  11. Therapeutic effects of SKF-96365 on murine allergic rhinitis induced by OVA.International journal of immunopathology and pharmacology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Qinghua HuNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Cardiovascular Surgery, Xiangya Hospital, Central-South University, Changsha, Hunan 410078, China.
Azmi A AhmadNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
Thomas SeidelNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.
Chris HunterNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.
Molly StreiffNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
Linda NikolovaCore Research Facilities, Health Sciences Center, University of Utah, Salt Lake City, UT 84112, USA.
Kenneth W SpitzerNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.
Frank B SachseNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: frank.sachse@utah.edu.
University of Utah · US

Funding

Remodeling of the Transverse Tubular System and Ryanodine Receptor Clusters in DyR01HL094464 · NHLBI · UNIVERSITY OF UTAH · PI SACHSE, FRANK BERND · 2010 to 2014
$1.9M
Cellular Remodeling in Heart Failure and after LVAD UnloadingR01HL132067 · NHLBI · UNIVERSITY OF UTAH · PI DRAKOS, STAVROS GEORGE, SACHSE, FRANK BERND · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL094464NHLBI NIH HHS R01 HL132067
6 · The paper itself

Abstract

Transient receptor potential canonical 1 (TRPC1) protein is abundantly expressed in cardiomyocytes. While TRPC1 is supposed to be critically involved in cardiac hypertrophy, its physiological role in cardiomyocytes is poorly understood. We investigated the subcellular location of TRPC1 and its contribution to Ca

Indexed as

AnimalsAnimals, NewbornCalciumCytoskeletal ProteinsHeart VentriclesModels, BiologicalMyocytes, CardiacRabbitsRatsSarcolemmaSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesTRPC Cation ChannelsCalciumCytoskeletal ProteinsSarcoplasmic Reticulum Calcium-Transporting ATPasesTRPC Cation ChannelsCalcium signalingSarcoplasmic reticulumTRPC1 channelsVentricular myocyte

Identifiers

PMID31982426
PMCPMC7085981
OpenAlexW3003092374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.