ArticleChest2020
Bronchodilator Response Assessed by the Forced Oscillation Technique Identifies Poor Asthma Control With Greater Sensitivity Than Spirometry.
Article in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07364188 (Bronchodilator Response in COPD and Asthma), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Bronchodilator Response in COPD and Asthma: Correlation Between Spirometry, IOS Indices, and Dyspnea Relief
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Pooled it
- Impact of breathing frequency on respiratory oscillometry measurements: a randomised cross-over and observational study of asthma patients.BMJ open respiratory research · 2026Trial
- A randomized double-blinded trial to assess recurrence of systemic allergic reactions following COVID-19 mRNA vaccination.The Journal of allergy and clinical immunology · 2024Trial
- Effect of Tezepelumab on Lung Function in Patients With Severe, Uncontrolled Asthma in the Phase 3 NAVIGATOR Study.Advances in therapy · 2023Trial
- Current use and future potential of oscillometry in UK lung function testing: a national survey.BMJ open respiratory research · 2026Article
- Predicting clinical exacerbations using respiratory oscillometry during home telemonitoring of patients taking medium-/high-dose asthma treatment.ERJ open research · 2026Article
- Bronchodilation response, respiratory burden and biomarkers: insights from impulse oscillometry and spirometry.ERJ open research · 2026Article
- Impulse oscillometry and traditional pulmonary function testing: correlation, advances and clinical implications.BMJ open respiratory research · 2026Review
- Association between impulse oscillometry Z-scores and asthma control and exacerbation risk in a tertiary severe asthma clinic.Frontiers in allergy · 2026Article
- Interpreting respiratory oscillometry in adults with asthma or COPD: findings of an international Delphi study.ERJ open research · 2025Article
- Comparison of oscillometry with lung function parameters between patients with stable bronchial asthma with airflow obstruction and chronic obstructive pulmonary disease.BMC pulmonary medicine · 2025Article
- The Impact of Age and Disease Entity on Small Airway Dysfunction in Obstructive Airway Diseases.International journal of chronic obstructive pulmonary disease · 2025Article
- Impact of environmental air pollution on respiratory health and function.Physiological reports · 2024Review
- Changes in fractional exhaled nitric oxide, forced expiratory volume in one second, and forced oscillation technique parameters over three years in adults with bronchial asthma managed under Yokohama Seibu Hospital's coordinated care system.BMC pulmonary medicine · 2024Article
- Improving asthma outcomes: Clinicians' perspectives on peripheral airways.The journal of allergy and clinical immunology. Global · 2024Article
- Clinical characterization and outcomes of impulse oscillometry-defined bronchodilator response: an ECOPD cohort-based study.Respiratory research · 2024Observational
- The Impact of Heat-Not-Burn, E-Cigarettes, and Cigarettes on Small Airway Function.Tobacco use insights · 2024Article
- Oscillometry and spirometry are not interchangeable when assessing the bronchodilator response in children and young adults born preterm.Pediatric pulmonology · 2023Article
- Role of small airway dysfunction in unexplained exertional dyspnoea.ERJ open research · 2023Article
- Oscillometry bronchodilator response in adult moderate to severe eosinophilic asthma patients: A prospective cohort study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
Corrections and comments
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersistent bronchodilator response (BDR) following diagnosis of asthma is an underrecognized treatable trait, associated with worse lung function and asthma control. The forced oscillation technique (FOT) measures respiratory system impedance, and BDR cutoffs have been proposed for healthy adults; however, the relevance in asthma is unknown. We compared BDR cutoffs, using FOT and spirometry, in asthma and the relationship with asthma control.
methodsData from patients with asthma who withheld bronchodilator medication for at least 8 h before a tertiary airway clinic visit were reviewed. All subjects performed FOT and spirometry before and after salbutamol administration, and completed the Asthma Control Test. FOT parameters examined included respiratory system resistance (R5) and reactance (X5) at 5 Hz, and area under the reactance curve (AX). BDR was defined by standard recommendations for spirometry and based on the 95th percentile of BDR in healthy adults for FOT.
resultsFifty-two subjects (18 men; mean age, 53 ± 18 years) were included. BDR was identified more frequently by FOT than spirometry (54% vs 27% of subjects). BDR assessed by X5 and AX, but not R5, was associated with spirometric BDR (χ
conclusionsBDR assessed by FOT can identify poor asthma control. Reactance parameters were more sensitive in identifying poor asthma control than spirometry, supporting the use of FOT to complement spirometry in the clinical management of asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.