ArticleOphthalmology. Retina2020
Ultra-Widefield Protocol Enhances Automated Classification of Diabetic Retinopathy Severity with OCT Angiography.
Article in Ophthalmology. Retina, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent advances and applications of optical coherence tomography angiography in diabetic retinopathy.Frontiers in endocrinology · 2025Pooled it
- Robust wavefront correction using AdamW-enhanced SPGD for computational adaptive optics in optical coherence tomography.Biomedical optics express · 2026Article
- Using OCT Angiography to Predict Diabetic Retinopathy Progression and Vision Decline in a Multiethnic Cohort.Ophthalmology science · 2026Article
- Evaluation of Vascular Biomarkers in Diabetic Retinopathy Using Ultrawide-Field Swept-Source Optical Coherence Tomography Angiography: The DRIVE Study.Investigative ophthalmology & visual science · 2026Article
- Volumetric montaging of optical coherence tomography in human retinas.bioRxiv : the preprint server for biology · 2026Article
- Albuminuria, but not eGFR, tracks diabetic retinopathy severity and retinal ischemia: population-based discovery, clinical replication, and OCTA evidence.Frontiers in endocrinology · 2026Article
- Wide-field OCTA quantified peripheral nonperfusion areas predict the risk of subclinical neovascularization.Eye (London, England) · 2025Article
- Rapid-onset neovascular glaucoma following cataract surgery in diabetes: outcomes of pars plana vitrectomy combined with Ahmed glaucoma valve implantation.International journal of ophthalmology · 2025Article
- The Role of Widefield Optical Coherence Tomography Angiography in Assessing the Severity of Diabetic Retinopathy.Ophthalmology and therapy · 2024Article
- Clinical Utilisation of Wide-Field Optical Coherence Tomography and Angiography: A Narrative Review.Ophthalmology and therapy · 2024Review
- Visualizing features with wide-field volumetric OCT angiography.Optics express · 2024Article
- Optical Coherence Tomography Angiography as a Diagnostic Tool for Diabetic Retinopathy.Diagnostics (Basel, Switzerland) · 2024Review
- Single-shot OCT and OCT angiography for slab-specific detection of diabetic retinopathy.Biomedical optics express · 2023Article
- Is There a Nonperfusion Threshold on OCT Angiography Associated With New Vessels Detected on Ultra-Wide-Field Imaging in Diabetic Retinopathy?Translational vision science & technology · 2023Article
- Assessing the Sensitivity of OCT-A Retinal Vasculature Metrics.Translational vision science & technology · 2023Article
- Extended and adjustable field-of-view of variable interscan time analysis by ammonite-scanning swept-source optical coherence tomography angiography.Biomedical optics express · 2023Article
- Multiple instance learning based classification of diabetic retinopathy in weakly-labeled widefield OCTA en face images.Scientific reports · 2023Article
- Clinically Significant Nonperfusion Areas on Widefield OCT Angiography in Diabetic Retinopathy.Ophthalmology science · 2023Article
- Peripheral and central capillary non-perfusion in diabetic retinopathy: An updated overview.Frontiers in medicine · 2023Review
- Different scan areas affect the detection rates of diabetic retinopathy lesions by high-speed ultra-widefield swept-source optical coherence tomography angiography.Frontiers in endocrinology · 2023Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeTo assess the diagnostic usefulness of retinal nonperfusion to classify eyes based on diabetic retinopathy (DR) severity on OCT angiography (OCTA) and determine whether wider field of view (FOV) OCTA protocols enhance the diagnostic usefulness of retinal nonperfusion in the classification of DR severity.
designRetrospective cross-sectional study.
participantsDiabetic patients undergoing ultra-widefield (UWF) OCTA imaging at 1 academic retina practice.
methodsUltra-widefield OCTA images with 100° FOV were obtained from 60 eyes. Eyes were grouped as those with diabetes without retinopathy (DWR), those with nonproliferative diabetic retinopathy (NPDR), or those with proliferative diabetic retinopathy (PDR). The ratio of nonperfusion (RNP) was expressed as the percent area of capillary nonperfusion within the FOV. The RNP was obtained in the FOV 100° image and concentric sectors encompassing 10°, 10° to 30°, 30° to 50°, and 50° to 100°.
main outcome measuresMean RNP among DR groups, mean RNP measured among FOV sectors, and area under the curve (AUC) of the receiver operating characteristics when using RNP as a cutoff value to distinguish between DR groups.
resultsMean RNP from the FOV 50° to 100° sector was different among all groups: DWR, 14.6±5.1%; NPDR, 27.5±7.5%; and PDR, 41.5±19.1% (P < 0.01). Within each DR group, field of view from 50° to 100° measured higher RNP than all other sectors (P < 0.01). Field of view from 50° to 100° showed the highest optimal sensitivity and specificity to distinguish NPDR from DWR with an RNP cutoff value of 21.2% (89.5% and 88.2%; AUC, 0.944) and PDR from NPDR with an RNP cutoff value of 31.6% (79.2% and 78.9%; AUC, 0.752).
conclusionsRatio of nonperfusion on average is higher in more severe DR. The most peripheral sector of the widefield OCTA (FOV 50°-100°) showed on average higher RNP and showed more diagnostic usefulness in determining DR severity compared with more central sectors and the FOV 100 image as a whole.
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