Evidence map›Paper›PMID 31981912›Full record

ArticleBioorganic chemistry2020

Efficient synthesis of NIR emitting bis[2-(2'-hydroxylphenyl)benzoxazole] derivative and its potential for imaging applications.

Junfeng Wang, Hannah Baumann, Xiaoman Bi, Leah P Shriver, Zhaoda Zhang, Yi Pang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. A Step Toward an NIR-Emitting ESIPT Probe for Smart ZnChemical & biomedical imaging · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junfeng WangDepartment of Chemistry, The University of Akron, Akron, OH 44325, USA; Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Boston, MA, USA; Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149, 13th St, Charlestown, MA 02129, USA.
Hannah BaumannDepartment of Chemistry, The University of Akron, Akron, OH 44325, USA.
Xiaoman BiDepartment of Chemistry, The University of Akron, Akron, OH 44325, USA.
Leah P ShriverDepartment of Chemistry, The University of Akron, Akron, OH 44325, USA.
Zhaoda ZhangMartinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149, 13th St, Charlestown, MA 02129, USA.
Yi PangDepartment of Chemistry, The University of Akron, Akron, OH 44325, USA; Maurice Morton Institute of Polymer Science, The University of Akron, Akron, OH 44325, USA. Electronic address: yp5@uakron.edu.

Funding

Chemical Probes for In Vivo Fibrin ImagingR01CA197401 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ZHANG, ZHAODA · 2015 to 2017
$1.4M
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
NIR-Emitting Fluorescent Probes with Large Stokes Shift for Improved Zebrafish Neuromast ImagingR15GM126438 · NIGMS · UNIVERSITY OF AKRON · PI PANG, YI · 2018 to 2018
$417k
NCI NIH HHS R01 CA197401NIGMS NIH HHS R15 GM126438NIH HHS S10 OD025234
6 · The paper itself

Abstract

Unassymetric bis[2-(2'-hydroxyphenylbenzoxole)] bis(HBO) derivatives with a DPA functionality for zinc binding have been developed with an efficient synthetic route, using the retrosynthetic analysis. Comparison of bis(HBO) derivatives with different substitution patterns allows us to verify and optimize their unique fluorescence properties. Upon binding zinc cation, bis(HBO) derivatives give a large fluorescence turn-on in both visible (λ

Indexed as

BenzoxazolesChelating AgentsFluorescenceFluorescent DyesHEK293 CellsHeLa CellsHumansMicroscopy, ConfocalMicroscopy, FluorescenceOptical ImagingThrombosisZincBenzoxazolesChelating AgentsFluorescent DyesZincBenzoxazoleESIPTFluorescent probeNear infraredThrombus imagingZinc

Identifiers

PMID31981912
PMCPMC7159060

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.