Evidence map›Paper›PMID 31981756›Full record

Observational studyBiochimica et biophysica acta. Molecular and cell biology of lipids2020

A single nucleotide polymorphism of PLIN2 is associated with nonalcoholic steatohepatitis and causes phenotypic changes in hepatocyte lipid droplets: A pilot study.

Claire S Faulkner, Collin M White, Vijay H Shah, Loretta L Jophlin

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. A missense variant in human perilipin 2 (JHEP reports : innovation in hepatology · 2024
    Article
  6. Review
  7. Article
  8. Perilipins at a glance.Journal of cell science · 2022
    Article
  9. Review
  10. Review
  11. Mitochondrial Mutations and Genetic Factors Determining NAFLD Risk.International journal of molecular sciences · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Claire S FaulknerUniversity of Nebraska Medical Center (UNMC), Department of Internal Medicine, Omaha, NE, United States of America; Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, MN, United States of America.
Collin M WhiteWashington University, St. Louis, MO, United States of America.
Vijay H ShahMayo Clinic, Division of Gastroenterology and Hepatology, Rochester, MN, United States of America.
Loretta L JophlinUniversity of Nebraska Medical Center (UNMC), Department of Internal Medicine, Omaha, NE, United States of America; Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, MN, United States of America. Electronic address: jophlin.loretta@mayo.edu.
University of Nebraska Medical Center · USMayo Clinic in Arizona · USWashington University in St. Louis · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Apar Kishor Ganti · 1985 to 2026
$55.0M
Tracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RIZZO, MATTHEW · 2016 to 2025
$42.8M
PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI GREGORY J. GORES · 2009 to 2026
$22.2M
UNMC Histology/Imaging and Creighton University Imaging Core FacilityP30GM110768 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SMITH, SHELLEY D · 2014 to 2018
$5.1M
Research Pilot Project ProgramP30GM106397 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI JOHNSON, KEITH R · 2013 to 2017
$4.9M
NCI NIH HHS P30 CA036727NIDDK NIH HHS P30 DK084567NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P30 GM106397NIGMS NIH HHS P30 GM110768NIGMS NIH HHS U54 GM115458
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic Predisposition to DiseaseCase-Control StudiesCell Line, TumorDNA Mutational AnalysisFemaleHepatocytesHumansLipid DropletsLiverMaleMiddle AgedMutagenesis, Site-DirectedNon-alcoholic Fatty Liver DiseasePerilipin-2Pilot ProjectsPolymerase Chain ReactionPerilipin-2PLIN2 protein, humanRecombinant ProteinsHepatic steatosisLipid dropletNonalcoholic steatohepatitisPerilipin-2Single nucleotide polymorphism

Identifiers

PMID31981756
PMCPMC8108536
OpenAlexW3002312315

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.