Evidence map›Paper›PMID 31981446›Full record

ArticleMolecular oncology2020

Prognostic significance of PD-L1 expression on cell-surface vimentin-positive circulating tumor cells in gastric cancer patients.

Mengyuan Liu, Ruoyu Wang, Xuren Sun, Yuting Liu, Zhi Wang, Jin Yan, Xiangyu Kong, Shanshan Liang, Qiuge Liu, Tong Zhao and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Mengyuan LiuDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Ruoyu WangDepartment of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
Xuren SunDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yuting LiuDepartment of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
Zhi WangDepartment of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
Jin YanDepartment of Gastrointestinal Surgery, Affiliated Zhongshan Hospital of Dalian University, China.
Xiangyu KongDepartment of Gastrointestinal Surgery, Affiliated Zhongshan Hospital of Dalian University, China.
Shanshan LiangDepartment of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
Qiuge LiuDepartment of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
Tong ZhaoDepartment of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
Xuening JiDepartment of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
Gang WangDepartment of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
Fuguang WangDepartment of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
Guan WangDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Liang ChenDepartment of Computer Science, College of Engineering, Shantou University, China.
Qingfu ZhangDepartment of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China.
Weipeng LvDepartment of Pathology, Affiliated Zhongshan Hospital of Dalian University, China.
Heming LiDepartment of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
Mingjun SunDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China.ORCID 0000-0001-8748-4658
Affiliated Zhongshan Hospital of Dalian University · CNFirst Hospital of China Medical University · CNChina Medical University · CNShantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although circulating tumor cells (CTCs) have shown promise as potential biomarkers for diagnostic and prognostic assessment in gastric cancer (GC), determining the predictive and prognostic value of programmed death-ligand 1 (PD-L1)-positive CTCs in patients with GC is a challenge. Here, we identified that the expression of total vimentin (VIM) protein was positively correlated with PD-L1 and inhibited CD8

Indexed as

B7-H1 AntigenBiomarkers, TumorFemaleHumansMaleMiddle AgedNeoplastic Cells, CirculatingPrognosisStomach NeoplasmsVimentinB7-H1 AntigenBiomarkers, TumorCD274 protein, humanVimentincell-surface vimentincirculating tumor cellsepithelial-mesenchymal transitiongastric cancerprogrammed cell death ligand 1

Identifiers

PMID31981446
PMCPMC7138401
OpenAlexW3002519518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.