Evidence map›Paper›PMID 31981355›Full record

ReviewFEMS yeast research2020

Transcriptional control of hyphal morphogenesis in Candida albicans.

Sonia Villa, Mohammad Hamideh, Anthony Weinstock, Mohammad N Qasim, Tony R Hazbun, Adnane Sellam, Aaron D Hernday, Shankar Thangamani

Open access · bronzeAbstract readReview
In one paragraph

Review in FEMS yeast research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
1.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Outbreak ofFrontiers in microbiology · 2026
    Article
  10. Transboundary and emerging diseases · 2026
    Article
  11. ThemBio · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Roles of P-body factors inbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sonia VillaMasters in Biomedical Science Program, Midwestern University, 19555 N. 59th Ave. Glendale, AZ 85308, USA.
Mohammad HamidehMasters in Biomedical Science Program, Midwestern University, 19555 N. 59th Ave. Glendale, AZ 85308, USA.
Anthony WeinstockArizona College of Osteopathic Medicine, Midwestern University, 19555 N. 59th Ave. Glendale, AZ 85308, USA.
Mohammad N QasimQuantitative and Systems Biology Graduate Program, School of Natural Sciences, University of California, Merced, Merced, CA, 95343, USA.
Tony R HazbunDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Adnane SellamDepartment of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Université Laval, Quebec City, QC, Canada.
Aaron D HerndayQuantitative and Systems Biology Graduate Program, School of Natural Sciences, University of California, Merced, Merced, CA, 95343, USA.
Shankar ThangamaniDepartment of Pathology and Population Medicine, College of Veterinary Medicine, Midwestern University, 19555 N. 59th Ave. Glendale, AZ 85308, USA.
Midwestern University · USUniversity of California, Merced · USPurdue University West Lafayette · USUniversité Laval · CA

Funding

Development of a high-throughput assay for Candida albicans cell-type switchingR15AI137975 · NIAID · UNIVERSITY OF CALIFORNIA, MERCED · PI HERNDAY, AARON D · 2019 to 2019
$444k
NIAID NIH HHS R15 AI137975
6 · The paper itself

Abstract

Candida albicans is a multimorphic commensal organism and opportunistic fungal pathogen in humans. A morphological switch between unicellular budding yeast and multicellular filamentous hyphal growth forms plays a vital role in the virulence of C. albicans, and this transition is regulated in response to a range of environmental cues that are encountered in distinct host niches. Many unique transcription factors contribute to the transcriptional regulatory network that integrates these distinct environmental cues and determines which phenotypic state will be expressed. These hyphal morphogenesis regulators have been extensively investigated, and represent an increasingly important focus of study, due to their central role in controlling a key C. albicans virulence attribute. This review provides a succinct summary of the transcriptional regulatory factors and environmental signals that control hyphal morphogenesis in C. albicans.

Indexed as

AnimalsCandida albicansFungal ProteinsGene Expression Regulation, FungalGene Regulatory NetworksHumansHyphaeMiceTranscription FactorsVirulenceFungal ProteinsTranscription FactorsC. albicansenvironmental signalshyphaemorphogenesistranscription factor(s)

Identifiers

PMID31981355
PMCPMC7000152
OpenAlexW3000969918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.