ArticleDrug delivery and translational research2020
Carboxymethyl cellulose-based wafer enriched with resveratrol-loaded nanoparticles for enhanced wound healing.
Article in Drug delivery and translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Resveratrol's bibliometric and visual analysis from 2014 to 2023.Frontiers in plant science · 2024Pooled it
- The impact of resveratrol on skin wound healing, scarring, and aging.International wound journal · 2022Pooled it
- Cellulose and Its Derivatives-Based Skin Dressings: Design, Smart Advances and Applications.Pharmaceutics · 2026Review
- Enhancing Cannabidiol Apparent Solubility and Oral Delivery: Self-assembled Nanomicelles of Amphiphilic Block Copolymer with γ-Polyglutamic Acid-grafted Cholesterol.Pharmaceutical research · 2025Article
- Innovative Nanocomposites for Drug Delivery: A Novel Approach for Diabetic Foot Ulcer.Current drug delivery · 2025Review
- Greener healing: sustainable nanotechnology for advanced wound care.Discover nano · 2024Review
- Advancements in wound healing: integrating biomolecules, drug delivery carriers, and targeted therapeutics for enhanced tissue repair.Archives of microbiology · 2024Review
- Development of a Resveratrol Nanoformulation for the Treatment of Diabetic Retinopathy.Materials (Basel, Switzerland) · 2024Article
- Article
- Role of Polyphenols, Their Nano-formulations, and Biomaterials in Diabetic Wound Healing.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Formulation and evaluation of simvastatin cubosomal nanoparticles for assessing its wound healing effect.Scientific reports · 2023Article
- Formulation and physicochemical characterization of azithromycin-loaded cubosomes.Research in pharmaceutical sciences · 2023Article
- Emerging Effects of Resveratrol on Wound Healing: A Comprehensive Review.Molecules (Basel, Switzerland) · 2022Review
- An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Resveratrol-Induced Signal Transduction in Wound Healing.International journal of molecular sciences · 2021Review
- Nanocomposite systems for precise oral delivery of drugs and biologics.Drug delivery and translational research · 2021Review
- Targeting Antibacterial Effect and Promoting of Skin Wound Healing After Infected with Methicillin-ResistantInternational journal of nanomedicine · 2021Article
- Development of a Multivariate Predictive Dissolution Model for Tablets Coated with Cellulose Ester Blends.Pharmaceuticals (Basel, Switzerland) · 2020Article
- NED416, a novel synthetic Sirt1 activator, promotes cutaneous wound healing via the MAPK/Rho pathway.International journal of molecular medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to prepare and investigate the wound healing potential of carboxymethyl cellulose (CMC)-based wafers incorporated with resveratrol (RSV)-loaded cellulose acetate butyrate (CAB) NPs. Accordingly, RSV-CAB NPs were prepared using the solvent evaporation method. The effect of different formulation parameters (polymer content, surfactant concentration, and the volume ratio of aqueous phase to organic phase) on the properties of NPs was investigated using the Box-Behnken design. Then, the optimized NPs were incorporated in wafers comprising CMC combined with hydroxyl propyl methyl cellulose (HPMC) or chitosan. Hydration capacity, porosity, adhesive strength, and hardness of the prepared nanocomposite wafers were examined. Optimized formulation was spherical, showing the particle size, polydispersity index, zeta potential, encapsulation efficiency %, drug loading %, and release efficiency % of 248.5 nm, 0.38, - 1.59, 87.58, 25.94, and 67.10, respectively. The CMC-HPMC wafers exhibited higher porosity, hydration capacity, and adhesive performance, as compared with the CMC wafers alone and CMC-chitosan wafers. Wound healing test and histological evaluation in the excisional wounds of the rats showed that the RSV-NPs-wafers were more effective as a healing accelerator, in comparison to wafers without drug or those containing the free RSV. These results demonstrated the potential of the RSV-NPs-wafer in wound healing drug delivery applications. Graphical abstract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.