Evidence map›Paper›PMID 31981075›Full record

ReviewEndocrine pathology2020

Gallbladder Mixed Neuroendocrine-Non-neuroendocrine Neoplasm (MiNEN) Arising in Intracholecystic Papillary Neoplasm: Clinicopathologic and Molecular Analysis of a Case and Review of the Literature.

Amedeo Sciarra, Edoardo Missiaglia, Mounir Trimech, Emmanuel Melloul, Jean-Philippe Brouland, Christine Sempoux, Stefano La Rosa

Open access · greenAbstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Endocrine pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

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  7. Methylation-Based Characterization of a NewInternational journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Amedeo SciarraInstitute of Pathology, Lausanne University Hospital and University of Lausanne, 25 rue du Bugnon, CH-1011, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-7550-0312
Edoardo MissiagliaInstitute of Pathology, Lausanne University Hospital and University of Lausanne, 25 rue du Bugnon, CH-1011, Lausanne, Switzerland.
Mounir TrimechInstitute of Pathology, Lausanne University Hospital and University of Lausanne, 25 rue du Bugnon, CH-1011, Lausanne, Switzerland.
Emmanuel MelloulDepartment of Visceral Surgery, Lausanne University Hospital, 46 rue du Bugnon, 1011, Lausanne, Switzerland.
Jean-Philippe BroulandInstitute of Pathology, Lausanne University Hospital and University of Lausanne, 25 rue du Bugnon, CH-1011, Lausanne, Switzerland.
Christine SempouxInstitute of Pathology, Lausanne University Hospital and University of Lausanne, 25 rue du Bugnon, CH-1011, Lausanne, Switzerland.
Stefano La RosaInstitute of Pathology, Lausanne University Hospital and University of Lausanne, 25 rue du Bugnon, CH-1011, Lausanne, Switzerland. stefano.larosa@chuv.ch.ORCID https://orcid.org/0000-0003-1941-2403
University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) of the gallbladder are generally composed of adenocarcinoma and neuroendocrine carcinoma (NEC). Rare cases associated with intracholecystic papillary neoplasm (ICPN) have been reported. Although recent molecular data suggest that the different components of digestive MiNENs originate from a common precursor stem cell, this aspect has been poorly investigated in gallbladder MiNENs. We describe the clinicopathologic and molecular features of a MiNEN composed of ICPN, adenocarcinoma, and NEC. A 66-year-old woman presented with severe abdominal pain. She underwent radical cholecystectomy and an intracholecystic mass was found. Histologically, it was composed of ICPN associated with adenocarcinoma and large cell neuroendocrine carcinoma (LCNEC). The three components were positive for DNA repair proteins and p53. EMA was positive in the ICPN and adenocarcinoma components, while it was negative in the LCNEC. Heterogeneous expression of Muc5AC, cytokeratin 20, and CDX2 was only observed in the ICPN component. Cytokeratin 7 was diffusely positive in both adenocarcinoma and LCNEC components, while it was heterogeneously expressed in the ICPN. The copy number variation analysis showed overlapping results between the adenocarcinoma and LCNEC components with some minor differences with the ICPN component. The three tumor components showed the same mutation profile including TP53 mutation c.700T > C (p. Tyr234His), without mutations in other 51 genes known to be frequently altered in cancer pathogenesis and growth. This finding may support the hypothesis of a monoclonal origin of the different tumor components. We have also performed a review of the literature on gallbladder MiNENs.

Indexed as

AdenocarcinomaAdenocarcinoma, PapillaryAgedBiomarkers, TumorCarcinoma, NeuroendocrineFemaleGallbladder NeoplasmsHumansMutationNeoplasms, Multiple PrimaryTumor Suppressor Protein p53Biomarkers, TumorTP53 protein, humanTumor Suppressor Protein p53GallbladderMANECMiNENMixed neuroendocrine-non-neuroendocrine neoplasm

Identifiers

PMID31981075
OpenAlexW3002410852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.