Evidence map›Paper›PMID 31981074›Full record

ArticleMolecular neurobiology2020

Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model.

Simrika Thapa, Dalia H Abdelaziz, Basant A Abdulrahman, Hermann M Schatzl

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simrika Thapa *Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.
Dalia H Abdelaziz *Calgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.
Basant A AbdulrahmanCalgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada.
Hermann M SchatzlCalgary Prion Research Unit, University of Calgary, Calgary, Alberta, Canada. hschaetz@ucalgary.ca.ORCID http://orcid.org/0000-0003-4972-8740

Funding

Alberta Innovates/Alberta Prion Research Institute 201600010Alberta Innovates - Health Solutions PDF FellowshipAlberta Innovates - Health Solutions PhD FellowshipKillam Trusts PhD FellowshipUniversity of Calgary Eyes High PhD Fellowship
6 · The paper itself

Abstract

Prion diseases are fatal infectious neurodegenerative disorders in human and animals caused by misfolding of the cellular prion protein (PrP

Indexed as

AnimalsCell Line, TumorDrug Evaluation, PreclinicalDrug SynergismEndoplasmic Reticulum StressEukaryotic Initiation Factor-2GuanabenzMetforminMiceNeuroblastomaNeuroprotective AgentsPhosphorylationPrionsProtein Phosphatase 1Protein Processing, Post-TranslationalProtein Serine-Threonine KinaseseIF2alpha kinase, mouseEukaryotic Initiation Factor-2GuanabenzMetforminNeuroprotective AgentsPrionsProtein Phosphatase 1Protein Serine-Threonine KinasesPrPC ProteinsPrPSc Proteinssephin1ER stressPrionPrion infectionProtein misfoldingSephin1UPR

Identifiers

PMID31981074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.