ArticleSleep & breathing = Schlaf & Atmung2020
Independent association of severity of obstructive sleep apnea with lipid metabolism of atherogenic index of plasma (AIP) and apoB/apoAI ratio.
Article in Sleep & breathing = Schlaf & Atmung, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Composite lipid indices in patients with obstructive sleep apnea: a systematic review and meta-analysis.Lipids in health and disease · 2023Pooled it
- Associations of work-related stress and total sleep time with cholesterol levels in an occupational cohort of Japanese office workers.Journal of occupational health · 2021Trial
- Beyond the Apnea-Hypopnea Index: Circulating Biomarkers and Device-Based Metrics for Cardiometabolic Risk Stratification in Obstructive Sleep Apnea.Journal of clinical medicine · 2026Review
- Hypoxemia burden and atherogenic indices in OSAS: changes after CPAP therapy.Frontiers in medicine · 2026Article
- Exploring the cardiometabolic profile of Emirati adults at risk for obstructive sleep apnea: findings from the UAE healthy future study.Frontiers in sleep · 2026Article
- Association between obstructive sleep apnea risk and atherosclerosis: A nationwide cross-sectional study in the Korean population.PloS one · 2025Article
- Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and atherogenic index of plasma with obstructive sleep apnea.Frontiers in psychiatry · 2025Article
- Prognostic value of the atherogenic index of plasma in patients with acute coronary syndrome without standard modifiable risk factors: a machine learning-based cohort study.Frontiers in cardiovascular medicine · 2025Article
- The relationship between composite lipid indices and baveno classification in patients with obstructive sleep apnoea.Scientific reports · 2024Article
- Association between the triglyceride glucose index and obstructive sleep apnea and its symptoms: results from the NHANES.Lipids in health and disease · 2024Article
- A Machine Learning Prediction Model of Adult Obstructive Sleep Apnea Based on Systematically Evaluated Common Clinical Biochemical Indicators.Nature and science of sleep · 2024Article
- Traditional and nontraditional lipid parameters inBiomarkers in medicine · 2024Article
- Sex Differences in the Efficacy of Mediterranean Diet Treatment: A Nutrigenomics Pilot Study.Genes · 2023Article
- Association between nontraditional lipid profiles and the severity of obstructive sleep apnea: A retrospective study.Journal of clinical laboratory analysis · 2023Article
- High-density lipoprotein cholesterol efflux capacity in patients with obstructive sleep apnea and its relation with disease severity.Lipids in health and disease · 2022Article
- Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia.Biomedicines · 2022Review
- Correlation of cardiovascular risk predictors with overweight and obesity in patients with familial hypercholesterolemia.Frontiers in cardiovascular medicine · 2022Article
- Comparison of Composite Lipid Indices in Patients with Obstructive Sleep Apnoea.Nature and science of sleep · 2022Article
- Atherogenic Index of Plasma in Obstructive Sleep Apnoea.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiovascular diseases (CVDs) are highly prevalent in obstructive sleep apnea (OSA), and dyslipidemia is an important factor. Atherogenic index of plasma (AIP, log[TG/HDL-C]) and apolipoproteinB to apolipoproteinAI ratio (apoB/apoAI ratio) are considered high quality predictors of cardiovascular risk. However, the associations between OSA severity and AIP and apoB/apoAI ratio remained unclear.
methodsA retrospective study was performed in 284 patients. Subjects were assessed with polysomnography (PSG) test, and OSA severity was defined by AHI. Data collected included anthropometric measurements, medical history, sleep parameters, fasting plasma lipids, fasting blood glucose, and insulin.
resultsParticipants were classified based on AHI into the following groups: control group (n = 28), mild group (n = 52), moderate group (n = 53), and severe group (n = 151). Triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), apoAI, AIP, apoB/apoAI ratio (low-density lipoprotein cholesterol), LDL-C/HDL-C ratio, and HDL-C/apoAI ratio showed statistical significance among AHI subgroups (P < 0.05). The Pearson correlation analysis revealed that AIP (r = 0.32, P < 0.001) and apoB/apoAI ratio (r = 0.24, P < 0.001) were positively related to AHI. By multivariate linear regression analysis, we found that AHI was independently related to AIP (β = 0.24, P = 0.001), apoB/apoAI ratio (β = 0.24, P<0.001).
conclusionAHI was independently correlated with AIP and apoB/apoAI ratio in OSA. Our findings suggested that AIP and apoB/apoAI ratio increased with OSA severity, which might be partly responsible for the high risk of CVDs in OSA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.