ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2020
Sequential analysis of heart rate variability, blood pressure variability and baroreflex sensitivity in healthy pregnancy.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- DHA Supplementation During Pregnancy Enhances Maternal Vagally Mediated Cardiac Autonomic Control in Humans.The Journal of nutrition · 2023Trial
- Extensive Intracerebral Hemorrhage Involving Basal Ganglia and Frontal Lobe With Intraventricular and Subarachnoid Extension in a Triplet Pregnancy Following In Vitro Fertilization: A Case Report and Review.Clinical case reports · 2026Article
- Attenuation of short-term autonomic cardiovascular responses with advancing gestational age.Frontiers in physiology · 2026Article
- Article
- Assessment of Sleep-wake State-associated Dynamic Changes in Heart Rate Variability in Female Rat: Autonomic System Modelling Approaches for Studying Behavioural Dysregulation.Annals of neurosciences · 2025Article
- Impact of Depressive Symptoms during the Second Trimester of Pregnancy on Maternal and Fetal Heart Rate Variability.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- A Scoping Review of Studies Reporting Heart Rate Variability Measurement Among Pregnant and Postpartum People Using Wearable Technology.Biological research for nursing · 2025Article
- Cardiac automaticity is modulated by IKACh in sinoatrial node during pregnancy.Cardiovascular research · 2024Article
- Postpartum Blood Pressure Variability and Heart Rate Variability in Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Autonomic Dysfunction and Cardiac Performance in Pregnant Women with Hypertensive Disorders: A Comparative Study Using Heart Rate Variability and Global Longitudinal Strain.Life (Basel, Switzerland) · 2024Article
- Maternal heart rate variability at 3-months postpartum is associated with maternal mental health and infant neurophysiology.Scientific reports · 2024Article
- Changes in Heart Rate, Heart Rate Variability, Breathing Rate, and Skin Temperature throughout Pregnancy and the Impact of Emotions-A Longitudinal Evaluation Using a Sensor Bracelet.Sensors (Basel, Switzerland) · 2023Observational
- Increased respiratory modulation of cardiovascular control reflects improved blood pressure regulation in pregnancy.Frontiers in physiology · 2023Article
- The Utilization of Heart Rate Variability for Autonomic Nervous System Assessment in Healthy Pregnant Women: Systematic Review.JMIR bioinformatics and biotechnology · 2022Review
- Characterizing the effect of demographics, cardiorespiratory factors, and inter-subject variation on maternal heart rate variability in pregnancy with statistical modeling: a retrospective observational analysis.Scientific reports · 2022Observational
- Trends in Heart Rate and Heart Rate Variability During Pregnancy and the 3-Month Postpartum Period: Continuous Monitoring in a Free-living Context.JMIR mHealth and uHealth · 2022Article
- Stress and autonomic nerve dysfunction monitoring in perioperative gastric cancer patients using a smart device.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022Observational
- Longitudinally Tracking Maternal Autonomic Modulation During Normal Pregnancy With Comprehensive Heart Rate Variability Analyses.Frontiers in physiology · 2022Article
- Impaired vagal adaptation to an exercise task in women with gestational diabetes mellitus versus women with uncomplicated pregnancies.Hormones (Athens, Greece) · 2021Article
- Association of heart rate variability, blood pressure variability, and baroreflex sensitivity with gastric motility at rest and during cold pressor test.Gastroenterology and hepatology from bed to bench · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to demonstrate the temporal profile of changes in heart rate variability (HRV), blood pressure variability (BPV), and cardiac baroreflex sensitivity (BRS) during the course of a healthy pregnancy. MATERIALS AND
methodsThis was a longitudinal study during which autonomic variability parameters (HRV, BPV, BRS) were assessed in 66 pregnant women at 11-13, 20-22 and 30-32 weeks of gestation. A lead II electrocardiogram tracing and beat-to-beat blood pressure were recorded with the subject breathing spontaneously in the supine position. Changes in the parameters were analyzed using repeated measures analysis of variance.
resultsOverall HRV (SDNN; standard deviation of all NN intervals) was found to decrease significantly over the course of pregnancy (p < 0.05). Similarly, indices which represent the parasympathetic component of these variables (SDSD [standard deviation of differences between adjacent NN intervals]; pNN50 [NN50 count {number of pairs of adjacent NN intervals differing by more than 50 ms} divided by the total number of all NN intervals]; high-frequency [HF] power) were also found to decrease significantly from the first to third trimester of pregnancy (p < 0.05). Low-frequency (LF) power increased over the course of pregnancy (p < 0.05). The LF/HF ratio increased significantly from first to third trimester of pregnancy (median: 0.66 [first trimester] vs.1.02 [second] vs. 0.91 [third]; p < 0.05) Overall BPV increased during the course of pregnancy, with a significant rise in the HF component of BPV and a significant fall in the LF component of BPV with advancing gestation (p < 0.05). BRS decreased over the course of pregnancy (median: 16.31, interquartile range [IQR] 11.04-23.13 [first trimester] vs. 11.42, IQR 8.54-19.52 [second] vs. 8.84, IQR 7.15-12.45 [third] ms/mmHg; p < 0.05).
conclusionPregnancy is associated with decreased vagal and increased sympathetic modulation of cardiac autonomic tone with advancing gestation, together with increased BPV. The reduction in cardiac BRS may play a role in increasing BPV and decreasing HRV over the course of pregnancy.
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