ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2020
Transport of maternal transthyretin to the fetus in the viviparous teleost Neoditrema ransonnetii (Perciformes, Embiotocidae).
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Proteomic analysis reveals dynamic changes in cloacal fluid composition during the reproductive season in a sexually promiscuous passerine.Scientific reports · 2024Article
- The interaction of zinc with the multi-functional plasma thyroid hormone distributor protein, transthyretin: evolutionary and cross-species comparative aspects.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Review
- The Role of the Thyroid Axis in Fish.Frontiers in endocrinology · 2020Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular basis of viviparity in non-mammalian species has not been widely studied. Neoditrema ransonnetii, a surfperch, is a matrotrophic teleost whose fetuses grow by ovarian cavity fluid (OCF) ingestion and by nutrient absorption via their enlarged hindgut. We performed a proteomics analysis of N. ransonnetii plasma protein and found proteins specific to pregnant females; one of these was identified as transthyretin (TTR), a thyroid hormone distributor protein. We synthesized recombinant protein rNrTTR and raised an antibody, anti-rNrTTR, against it. Semi-quantitative analysis by western blotting using the antibody demonstrated that plasma TTR levels were significantly greater in pregnant fish than in non-pregnant fish. OCF and fetal plasma also contained high TTR levels. Immunohistochemical staining showed that large amounts of maternal TTR were taken up by fetal intestinal epithelial cells. These results indicate that maternal TTR is secreted into OCF and taken up by fetal enterocytes, presumably to deliver thyroid hormones to developing fetuses.
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