Evidence map›Paper›PMID 31980848›Full record

Observational studyPediatric radiology2020

Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients.

Nanae Tsuchiya, Mark L Schiebler, Michael D Evans, Robert V Cadman, Ronald L Sorkness, Robert F Lemanske, Daniel J Jackson, Nizar N Jarjour, Loren C Denlinger, Sean B Fain

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pulmonary MRI in Newborns and Children.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nanae TsuchiyaDepartment of Radiology, University of Wisconsin-Madison, 111 Highland Ave., 2488 WIMR, Madison, WI, 53705, USA.
Mark L SchieblerDepartment of Radiology, University of Wisconsin-Madison, 111 Highland Ave., 2488 WIMR, Madison, WI, 53705, USA.
Michael D EvansDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
Robert V CadmanDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Ronald L SorknessDepartment of Pediatrics-Allergy, Immunology & Rheumatology, University of Wisconsin-Madison, Madison, WI, USA.
Robert F LemanskeDepartment of Pediatrics-Allergy, Immunology & Rheumatology, University of Wisconsin-Madison, Madison, WI, USA.
Daniel J JacksonDepartment of Pediatrics-Allergy, Immunology & Rheumatology, University of Wisconsin-Madison, Madison, WI, USA.
Nizar N JarjourDepartment of Medicine-Allergy, Pulmonary & Critical Care, University of Wisconsin-Madison, Madison, WI, USA.
Loren C DenlingerDepartment of Medicine-Allergy, Pulmonary & Critical Care, University of Wisconsin-Madison, Madison, WI, USA.
Sean B FainDepartment of Radiology, University of Wisconsin-Madison, 111 Highland Ave., 2488 WIMR, Madison, WI, 53705, USA. sfain@wisc.edu.ORCID 0000-0001-5461-0646
University of Wisconsin–Madison · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2002 to 2017
$31.3M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
Stability of Severe Asthma Phenotypes: Impact of ExacerbationsU10HL109168 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2011 to 2016
$3.9M
XeBox-E10 Gas Polarizer for Functional MRI of Pediatric Lung DiseaseS10OD016394 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI FAIN, SEAN BEDILION · 2013 to 2013
$600k
NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1 TR002373NHLBI NIH HHS P01 HL070831NHLBI NIH HHS R01 HL126771NHLBI NIH HHS U10 HL109168NIH HHS P01 HL070831NIH HHS R01 HL126771NIH HHS S10 OD016394NIH HHS U10 HL109168
6 · The paper itself

Abstract

backgroundHyperpolarized helium 3 magnetic resonance imaging (

objectiveTo evaluate the safety of MATERIALS AND

methodsThis was a retrospective observational study.

resultsThere were no serious adverse events, but three minor adverse events (2.3%; headache, dizziness and mild hypoxia) were reported. We found statistically significant increases in heart rate and SpO

conclusionThe use of

Indexed as

HeliumIsotopesAdolescentAsthmaChildFemaleHumansLungMagnetic Resonance ImagingMaleRetrospective StudiesHeliumHelium-3IsotopesAsthmaChildrenHeliumLungMagnetic resonance imagingSafety

Identifiers

PMID31980848
PMCPMC7153994
OpenAlexW3001757802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.