ArticleScientific reports2020
CREBBP and WDR 24 Identified as Candidate Genes for Quantitative Variation in Red-Brown Plumage Colouration in the Chicken.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Domestication effects on crowing in chickens: variation between wild and captive red junglefowl and domestic white Leghorn and the genetic architecture of crowing vocalizations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Open biology · 2023Article
- Genomic and gene expression associations to morphology of a sexual ornament in the chicken.G3 (Bethesda, Md.) · 2022Article
- A large and diverse autosomal haplotype is associated with sex-linked colour polymorphism in the guppy.Nature communications · 2022Article
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8 authors.
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Abstract
Plumage colouration in birds is important for a plethora of reasons, ranging from camouflage, sexual signalling, and species recognition. The genes underlying colour variation have been vital in understanding how genes can affect a phenotype. Multiple genes have been identified that affect plumage variation, but research has principally focused on major-effect genes (such as those causing albinism, barring, and the like), rather than the smaller effect modifier loci that more subtly influence colour. By utilising a domestic × wild advanced intercross with a combination of classical QTL mapping of red colouration as a quantitative trait and a targeted genetical genomics approach, we have identified five separate candidate genes (CREBBP, WDR24, ARL8A, PHLDA3, LAD1) that putatively influence quantitative variation in red-brown colouration in chickens. By treating colour as a quantitative rather than qualitative trait, we have identified both QTL and genes of small effect. Such small effect loci are potentially far more prevalent in wild populations, and can therefore potentially be highly relevant to colour evolution.
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