ArticleScientific reports2020
Autofluorescence mediated red spherulocyte sorting provides insights into the source of spinochromes in sea urchins.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 24 citations in OpenAlex.
- Carotenoid-based immune response in sea cucumbers relies on newly identified coelomocytes-the carotenocytes.Frontiers in immunology · 2025Article
- Environmental challenge trials induce a biofluorescent response in the green sea urchin Strongylocentrotus droebachiensis.Scientific reports · 2024Article
- In Vitro Anti-Inflammatory and Vasculoprotective Effects of Red Cell Extract from the Black Sea UrchinNutrients · 2023Article
- Evidence for association of Vibrio echinoideorum with tissue necrosis on test of the green sea urchin Strongylocentrotus droebachiensis.Scientific reports · 2022Article
- Multi-target bioactivity of summer quinones production in the Persian Gulf burrowing black-type sea urchin.Heliyon · 2022Article
- Coelomocyte populations in the sea urchin,Frontiers in immunology · 2022Article
- Chemical characterization of red cells from the black sea urchinRSC advances · 2021Article
- The Diverse Transformer (Trf) Protein Family in the Sea UrchinInternational journal of molecular sciences · 2021Article
- Spinochrome Identification and Quantification in Pacific Sea Urchin Shells, Coelomic Fluid and Eggs Using HPLC-DAD-MS.Marine drugs · 2021Article
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5 authors at 2 institutions in 1 country.
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Abstract
Red spherule cells (RSCs) are considered one of the prime immune cells of sea urchins, but their detailed biological role during immune responses is not well elucidated. Lack of pure populations accounts for one of the major challenges of studying these cells. In this study, we have demonstrated that live RSCs exhibit strong, multi-colour autofluorescence distinct from other coelomocytes, and with the help of fluorescence-activated cell sorting (FACS), a pure population of live RSCs was successfully separated from other coelomocytes in the green sea urchin, Strongylocentrotus droebachiensis. This newly developed RSCs isolation method has allowed profiling of the naphthoquinone content in these cells. With the use of ultra high-performance liquid chromatography, UV absorption spectra, and high-resolution tandem mass spectrometry, it was possible to identify sulphated derivatives of spinochrome C, D, E and spinochrome dimers, which suggests that the RSCs may play an important biological role in the biogenesis of naphthoquinone compounds and regulating their bioactivity.
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