ArticleNature communications2020
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS
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In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
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- Extensive peripheral immunoglobulin repertoire analyses in people with multiple sclerosis reveal disease-specific signatures and distinct treatment effects of disease modifying drugs.Journal of neuroinflammation · 2026Article
- SH3BGRL proteins are thioredoxin fold-containing actin filament pointed end capping proteins (TPECs).Scientific reports · 2026Article
- TRIM21 and OTUD6A orchestrate AKT K27-linked atypical ubiquitination to modulate cancer chemoresistance.Nature structural & molecular biology · 2026Article
- Pan-cancer molecular signatures connecting aspartate transaminase to cancer prognosis, metabolic and immune signatures.Frontiers in oncology · 2026Article
- Differential effects of KRAS G-domain and hypervariable region mutants on cancer phenotypes.Scientific reports · 2025Article
- Development of a Modular Ribonucleoprotein Complex as a General Strategy to Deliver RNAi Therapeutics.Advanced healthcare materials · 2025Article
- Focal Adhesion Kinase Intersects With the BRD4-MYC Axis and YAP1 to Drive Tumor Cell Growth, Phenotypic Plasticity, Stemness, and Metastatic Potential in Colorectal Cancer.Cancer medicine · 2025Article
- A feedforward loop between STAT1 and YAP1 stimulates lipid biosynthesis, accelerates tumor growth, and promotes chemotherapy resistance in mutant KRAS colorectal cancer.Communications biology · 2025Article
- Human dorsal forebrain organoids show differentiation-state-specific protein secretion.iScience · 2025Article
- MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathway.Cancer biology & therapy · 2024Article
- The mTOR pathway controls phosphorylation of BRAF at T401.Cell communication and signaling : CCS · 2024Article
- The value of protein allostery in rational anticancer drug design: an update.Expert opinion on drug discovery · 2024Review
- Article
- Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation.Molecular psychiatry · 2024Article
- TRIM26 inhibits clear cell renal cell carcinoma progression through destabilizing ETK and thus inactivation of AKT/mTOR signaling.Journal of translational medicine · 2024Article
- Transformation of an odontogenic keratocyst into a solid variant of odontogenic keratocyst/keratoameloblastoma during long‑term follow‑up: A case report.Molecular medicine reports · 2024Article
- Impact of KRAS mutation on the tumor microenvironment in colorectal cancer.International journal of biological sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 14 institutions in 10 countries.
Susan A Kennedy *Systems Biology Ireland, University College Dublin, Dublin, Ireland.
Mohamed-Ali Jarboui *Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-5203-235X
Sriganesh Srihari *EMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.
Cinzia Raso *Systems Biology Ireland, University College Dublin, Dublin, Ireland.
Kenneth BryanEMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.
Layal DernaykaInstitute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.
Theodosia CharitouSystems Biology Ireland, University College Dublin, Dublin, Ireland.
Manuel Bernal-LlinaresEMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.ORCID http://orcid.org/0000-0002-7368-180X
Carlos Herrera-MontavezSystems Biology Ireland, University College Dublin, Dublin, Ireland.
Aleksandar KrsticSystems Biology Ireland, University College Dublin, Dublin, Ireland.
David MatallanasSystems Biology Ireland, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-2360-3141
Max KotlyarKrembil Research Institute, University Health Network, Toronto, Canada.
Igor JurisicaKrembil Research Institute, University Health Network, Toronto, Canada.
Jasna CurakDonnelly Centre, University of Toronto, Toronto, Canada.
Victoria WongDonnelly Centre, University of Toronto, Toronto, Canada.
Igor StagljarDonnelly Centre, University of Toronto, Toronto, Canada.ORCID http://orcid.org/0000-0002-5260-3327
Thierry LeBihanSynthetic and Systems Biology, University of Edinburgh, Edinburgh, UK.
Lisa ImrieSynthetic and Systems Biology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1115-1720
Priyanka PillaiEMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.
Miriam A LynnEMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.
Erik FasteriusSchool of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-0492-9960
Cristina Al-Khalili SzigyartoSchool of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6990-1905
James BreenSchool of Biological Sciences, University of Adelaide Bioinformatics Hub, Adelaide, SA, Australia.
Christina KielSystems Biology Ireland, University College Dublin, Dublin, Ireland.
Luis SerranoCentre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0002-5276-1392
Nora RauchSystems Biology Ireland, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0001-6009-5177
Oleksii RukhlenkoSystems Biology Ireland, University College Dublin, Dublin, Ireland.
Boris N KholodenkoSystems Biology Ireland, University College Dublin, Dublin, Ireland.
Luis F Iglesias-MartinezSystems Biology Ireland, University College Dublin, Dublin, Ireland.
Colm J RyanSystems Biology Ireland, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0003-2750-9854
Ruth PilkingtonSystems Biology Ireland, University College Dublin, Dublin, Ireland.
Patrizia CammareriCancer Research UK Beatson Institute, Glasgow, UK.
Owen SansomCancer Research UK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0001-9540-3010
Steven ShaveSchool of Biological Sciences and School of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6996-3663
Manfred AuerSchool of Biological Sciences and School of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-8920-3522
Nicola HornInstitute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.
Franziska KloseInstitute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.
Marius UeffingInstitute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.
Karsten BoldtInstitute for Ophthalmic Research, University of Tübingen, Tübingen, Germany. karsten.boldt@uni-tuebingen.de.ORCID http://orcid.org/0000-0002-2693-689X
David J LynnEMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia. david.lynn@sahmri.com.
Walter KolchSystems Biology Ireland, University College Dublin, Dublin, Ireland. walter.kolch@ucd.ie.ORCID http://orcid.org/0000-0001-5777-5016
University College Dublin · IEUniversity of Tübingen · DEEMBL Australia · AUUniversity of Edinburgh · GBUniversity of Toronto · CACancer Research UK Scotland Institute · GBUniversity Health Network · CACentre for Genomic Regulation · ESFlinders University · AUKTH Royal Institute of Technology · SEQIMR Berghofer Medical Research Institute · AUScience for Life Laboratory · SESiemens (Germany) · DESouth Australian Health and Medical Research Institute · AU
Funding
Cancer Research UK 21139
Abstract
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRAS
Indexed as
Protein Interaction Mapsbcl-Associated Death ProteinCell Line, TumorCell Transformation, NeoplasticColorectal NeoplasmsErbB ReceptorsHumansMutationPhosphorylationPrognosisProto-Oncogene Proteins p21(ras)Survival Analysisbcl-Associated Death ProteinErbB ReceptorsKRAS protein, humanProto-Oncogene Proteins p21(ras)
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.