ArticleNature communications2020
A helitron-induced RabGDIα variant causes quantitative recessive resistance to maize rough dwarf disease.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 69 citations in OpenAlex.
- Blue Light Receptor PHR2-Mediated Spectrum Antiviral Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ZmNPSN13 Potentiates Maize Rough Dwarf Disease Upon Recruitment by the RBSDV P7-1 Effector.Molecular plant pathology · 2026Article
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Rice black-streaked dwarf virus-encoded P6 protein impairs OsPelota-mediated antiviral RNA decay defense via promoting OsSCE1b ubiquitination and degradation in rice.Journal of integrative plant biology · 2025Article
- Agricultural biotechnology in China: product development, commercialization, and perspectives.aBIOTECH · 2025Review
- A WRKY transcription factor confers broad-spectrum resistance to biotic stresses and yield stability in rice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- The ZmCPK39-ZmDi19-ZmPR10 immune module regulates quantitative resistance to multiple foliar diseases in maize.Nature genetics · 2024Article
- Crop antiviral defense: Past and future perspective.Science China. Life sciences · 2024Review
- ZmGDIα-hel counters the RBSDV-induced reduction of active gibberellins to alleviate maize rough dwarf virus disease.Nature communications · 2024Article
- ZmmiR398b negatively regulates maize resistance to sugarcane mosaic virus infection by targeting ZmCSD2/4/9.Molecular plant pathology · 2024Article
- Gene pyramiding ofMolecular breeding : new strategies in plant improvement · 2024Article
- The ZmWAKL-ZmWIK-ZmBLK1-ZmRBOH4 module provides quantitative resistance to gray leaf spot in maize.Nature genetics · 2024Article
- New resistance gene against maize rough dwarf disease identified in cereal crops.Nature plants · 2023Article
- A transcription factor ZmGLK36 confers broad resistance to maize rough dwarf disease in cereal crops.Nature plants · 2023Article
- The genetic architecture of prolificacy in maize revealed by association mapping and bulk segregant analysis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Integrated Molecular and Bioinformatics Approaches for Disease-Related Genes in Plants.Plants (Basel, Switzerland) · 2023Review
- Abundance of Transgene Transcript Variants Associated with Somatically Active TransgenicInternational journal of molecular sciences · 2023Article
- De novo genome assembly and analyses of 12 founder inbred lines provide insights into maize heterosis.Nature genetics · 2023Article
- A novel active transposon creates allelic variation through altered translation rate to influence protein abundance.Nucleic acids research · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maize rough dwarf disease (MRDD), caused by various species of the genus Fijivirus, threatens maize production worldwide. We previously identified a quantitative locus qMrdd1 conferring recessive resistance to one causal species, rice black-streaked dwarf virus (RBSDV). Here, we show that Rab GDP dissociation inhibitor alpha (RabGDIα) is the host susceptibility factor for RBSDV. The viral P7-1 protein binds tightly to the exon-10 and C-terminal regions of RabGDIα to recruit it for viral infection. Insertion of a helitron transposon into RabGDIα intron 10 creates alternative splicing to replace the wild-type exon 10 with a helitron-derived exon 10. The resultant splicing variant RabGDIα-hel has difficulty being recruited by P7-1, thus leading to quantitative recessive resistance to MRDD. All naturally occurring resistance alleles may have arisen from a recent single helitron insertion event. These resistance alleles are valuable to improve maize resistance to MRDD and potentially to engineer RBSDV resistance in other crops.
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