SynthesisNature communications2020
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity.
Synthesis in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 261 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
261 citing papers in PubMed, 8 syntheses or guidelines pooled it, 430 citations in OpenAlex.
- Multi-ancestry genome-wide association study of serum creatine kinase implicates myopathy genes and muscle pathways.EBioMedicine · 2026Pooled it
- Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Myonectin and metabolic health: a systematic review.Frontiers in endocrinology · 2025Pooled it
- PERM1-An Emerging Transcriptional Regulator of Mitochondrial Biogenesis: A Systematic Review.Genes · 2024Pooled it
- PROKR1-CREB-NR4A2 axis for oxidative muscle fiber specification and improvement of metabolic function.Proceedings of the National Academy of Sciences of the United States of America · 2024Pooled it
- Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle.Aging cell · 2024Pooled it
- Genes Whose Gain or Loss of Function Changes Type 1, 2A, 2X, or 2B Muscle Fibre Proportions in Mice-A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.Nature genetics · 2022Pooled it
- Acute nutritional ketosis during early recovery from aerobic exercise does not affect skeletal muscle transcriptomic response in humans.European journal of applied physiology · 2026Trial
- Transcriptomic response of skeletal muscle to acute aerobic versus combined exercise in chronic kidney disease.PloS one · 2026Trial
- Sprint interval exercise disrupts mitochondrial ultrastructure driving a unique mitochondrial stress response and remodelling in men.Nature communications · 2025Trial
- Testosterone Modulation of Muscle Transcriptomic Profile During Lifestyle Therapy in Older Men with Obesity and Hypogonadism.Journal of cachexia, sarcopenia and muscle · 2025Trial
- Digoxin and exercise effects on skeletal muscle NaExperimental physiology · 2024Trial
- Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults.Physiological genomics · 2023Trial
- MAFF is a transcription factor that regulates contraction-induced skeletal muscle transcription.Life science alliance · 2026Article
- Article
- Sarcopenia and 24-Month All-Cause Mortality in Patients Receiving Maintenance Hemodialysis: A Prospective Observational Cohort Study Applying the Revised European Working Group on Sarcopenia in Older People Criteria.Medicina (Kaunas, Lithuania) · 2026Observational
- Review
- Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses.Equine veterinary journal · 2026Article
- Treating age-related loss of muscle mass and function: Where should we be focusing?The Journal of physiology · 2026Review
201 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular mechanisms underlying the response to exercise and inactivity are not fully understood. We propose an innovative approach to profile the skeletal muscle transcriptome to exercise and inactivity using 66 published datasets. Data collected from human studies of aerobic and resistance exercise, including acute and chronic exercise training, were integrated using meta-analysis methods (www.metamex.eu). Here we use gene ontology and pathway analyses to reveal selective pathways activated by inactivity, aerobic versus resistance and acute versus chronic exercise training. We identify NR4A3 as one of the most exercise- and inactivity-responsive genes, and establish a role for this nuclear receptor in mediating the metabolic responses to exercise-like stimuli in vitro. The meta-analysis (MetaMEx) also highlights the differential response to exercise in individuals with metabolic impairments. MetaMEx provides the most extensive dataset of skeletal muscle transcriptional responses to different modes of exercise and an online interface to readily interrogate the database.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.