ArticleNature communications2020
PTH induces bone loss via microbial-dependent expansion of intestinal TNF
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 1 pooled it
11.7field-weighted citation impact, top 1% of its field
What it found
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Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Gut microbiome and bone health: update on mechanisms, clinical correlations, and possible treatment strategies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Pooled it
- Targeting the gut-bone axis in osteoporosis: probiotic interventions and other microbiota-based therapeutic strategies.Gut microbes · 2026Review
- The gut-bone axis: microbial metabolism and nutritional interventions for bone health.Gut microbes · 2026Review
- Article
- Osteoporosis from the perspective of the gut-bone axis: gut microbiota, metabolites, and multi-system synergistic regulation.Journal of endocrinological investigation · 2026Review
- Calcium Homeostasis and Parturient Paresis in Ruminants: Mechanistic Insights and Clinical Management.Animals : an open access journal from MDPI · 2026Review
- Links between bone fractures and the gut microbiota.Nature reviews. Endocrinology · 2026Review
- Bacterial specificity of the gut microbiome predicts bone density in primary hyperparathyroidism.Bone research · 2026Article
- Dried Ginger Milk Extract Alleviates Inflammatory Bowel Disease-Associated Bone Loss via Gut Microbiota-Metabolite Remodeling and MEK/ERK Inhibition.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Liver fraction of circulating alkaline phosphatase is elevated in chronic kidney disease and associates with mortality in patients treated with haemodialysis.Clinical kidney journal · 2026Article
- Intermittent parathyroid hormone (1-34) ameliorates periodontitis via Treg-dependent immunomodulation of the Treg/Th17 axis.Frontiers in immunology · 2026Article
- Bone Marrow Immunometabolic Remodeling in Osteoporosis: From Systemic Risk Factors to Precision Intervention.International journal of general medicine · 2026Review
- Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies.Research (Washington, D.C.) · 2026Review
- The role of gut microbiota in osteoporosis: underlying mechanisms, clinical associations, and emerging biomaterials.Frontiers in immunology · 2026Review
- Roles of gut metabolites on bone mineralization and remodeling: impact of metabolic dysregulation on the gut-immune-bone axis.Frontiers in endocrinology · 2026Review
- The role of gut microbiota-immune-endocrine crosstalk in the pathogenesis of osteoporosis.Frontiers in immunology · 2026Review
- Gut microbiota in chronic kidney disease-mineral and bone disorder: shared mechanisms, disease-specific signatures, and therapeutic prospects.Frontiers in endocrinology · 2026Review
- Microbial mechanisms and therapeutic interventions in the periodontitis-inflammatory bowel disease axis: a comprehensive review.Journal of oral microbiology · 2026Review
- Gut-bone axis: mechanisms and intervention effects of Chinese botanical drugs in osteoporosis management.Frontiers in pharmacology · 2026Review
- Rewiring osteoimmune homeostasis in osteoporosis: T-cell subsets as key regulators and emerging therapeutic targets.Frontiers in immunology · 2026Review
43 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Mingcan YuDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Abdul Malik TyagiDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Jau-Yi LiDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Jonathan AdamsDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Timothy L DenningCenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, USA.
M Neale WeitzmannDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA.
Rheinallt M JonesEmory Microbiome Research Center, Emory University, Atlanta, GA, USA.
Roberto PacificiDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA, USA. roberto.pacifici@emory.edu.
Emory University · USGeorgia State University · US
Funding
Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2MAccelerated Bone Loss in Aging HIV-infected IndividualsR01AR068157 · NIAMS · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WEITZMANN, MERVYN NEALE · 2015 to 2019
$3.3MIL-4, a key regulator of bone turnover in HIV and ARTR01AR070091 · NIAMS · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, WEITZMANN, MERVYN NEALE · 2016 to 2020
$3.2MRole of the gut microbiome in the bone loss induced by hyperparathyroidism in mice and humansR01DK124821 · NIDDK · EMORY UNIVERSITY · PI BILEZIKIAN, JOHN P, JONES, RHEINALLT MELFYN · 2021 to 2024
$2.4MRole of Gut Microbiota in Bone Mass Heritability and Skeletal Response to PTHR01DK119229 · NIDDK · EMORY UNIVERSITY · PI JONES, RHEINALLT MELFYN, PACIFICI, ROBERTO · 2019 to 2022
$2.3MMechanisms of Bone Anabolic and Anticatabolic Activities of ProbioticsR01DK112946 · NIDDK · EMORY UNIVERSITY · PI JONES, RHEINALLT MELFYN, PACIFICI, ROBERTO · 2018 to 2021
$2.0MThe molecular mechanisms of intestinal homeostasis.R01DK098391 · NIDDK · EMORY UNIVERSITY · PI JONES, RHEINALLT MELFYN · 2014 to 2017
$1.4MTh17 cells and Tregs determine the catabolic and anabolic effects of PTH in boneR01DK108842 · NIDDK · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2016 to 2018
$1.2MIn Vivo MicroCT ScannerS10RR028009 · NCRR · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 2010 to 2010
$494kImmune Regulation of Bone HomeostasisI01BX000105 · VA · VETERANS HEALTH ADMINISTRATION · PI WEITZMANN, MERVYN NEALE · 2009 to 2022
–BLRD VA I01 BX000105NCRR NIH HHS S10 RR028009NIAMS NIH HHS R01 AR068157NIAMS NIH HHS R01 AR070091NIA NIH HHS U54 AG062334NIDDK NIH HHS R01 DK098391NIDDK NIH HHS R01 DK108842NIDDK NIH HHS R01 DK112946NIDDK NIH HHS R01 DK119229NIDDK NIH HHS R01 DK124821
Abstract
Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the Th17 cell-inducing taxa segmented filamentous bacteria (SFB). SFB
Indexed as
AnimalsFecal Microbiota TransplantationFemaleGastrointestinal MicrobiomeGerm-Free LifeGram-Positive Endospore-Forming RodsHyperparathyroidism, PrimaryIntestinesMiceMice, Inbred C57BLMice, KnockoutOsteoporosisParathyroid HormoneTh17 CellsT-Lymphocyte SubsetsTumor Necrosis Factor-alphaParathyroid HormoneTumor Necrosis Factor-alpha
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.