Evidence map›Paper›PMID 31980578›Full record

ArticleRNA (New York, N.Y.)2020

An RNA pseudoknot stimulates HTLV-1

Eliza Thulson, Erik W Hartwick, Andrew Cooper-Sansone, Marcus A C Williams, Mary E Soliman, Leila K Robinson, Jeffrey S Kieft, Kathryn D Mouzakis

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Ribosome-induced mRNA pseudoknot interactions visualized by DMS MaP-Seq.bioRxiv : the preprint server for biology · 2025
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Eliza Thulson *Department of Chemistry and Biochemistry, Fort Lewis College, Durango, Colorado 81301, USA.ORCID 0000-0002-8760-3087
Erik W Hartwick *Department of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA.ORCID 0000-0001-9276-8567
Andrew Cooper-SansoneDepartment of Chemistry and Biochemistry, Fort Lewis College, Durango, Colorado 81301, USA.
Marcus A C WilliamsDepartment of Chemistry and Biochemistry, Fort Lewis College, Durango, Colorado 81301, USA.
Mary E SolimanDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, California 90045, USA.
Leila K RobinsonDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, California 90045, USA.
Jeffrey S KieftDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA.ORCID 0000-0002-3718-1891
Kathryn D MouzakisDepartment of Chemistry and Biochemistry, Loyola Marymount University, Los Angeles, California 90045, USA.ORCID 0000-0001-6355-8851
Fort Lewis College · USLoyola Marymount University · USUniversity of Colorado Denver · US

Funding

Structure, function, and dynamics of viral RNAs and RNA-containing complexesR35GM118070 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Jeffrey S Kieft · 2016 to 2026
$10.6M
Minority Research Training in Biomedical and Behavioral STEM Disciplines at FLCT34GM092711 · NIGMS · FORT LEWIS COLLEGE · PI FENSTER, STEVEN DANIEL · 2010 to 2020
$2.0M
Structural Basis of -1 Programmed Ribosomal Frameshifting by the Human T-cell Lymphotropic Virus Type I RNASC2GM121197 · NIGMS · FORT LEWIS COLLEGE · PI MOUZAKIS DE SILVA, KATHRYN DENISE · 2017 to 2018
$226k
NIGMS NIH HHS R35 GM118070NIGMS NIH HHS SC2 GM121197NIGMS NIH HHS T34 GM092711
6 · The paper itself

Abstract

Programmed -1 ribosomal frameshifts (-1 PRFs) are commonly used by viruses to regulate their enzymatic and structural protein levels. Human T-cell leukemia virus type 1 (HTLV-1) is a carcinogenic retrovirus that uses two independent -1 PRFs to express viral enzymes critical to establishing new HTLV-1 infections. How the

Indexed as

Frameshifting, RibosomalGene Expression Regulation, ViralHuman T-lymphotropic virus 1Nucleotide MotifsRibosomesRNA, MessengerRNA, Messengerchemical probingframeshiftingHTLV-1retrovirusRNA pseudoknottranslation

Identifiers

PMID31980578
PMCPMC7075266
OpenAlexW3001501520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.