Trial reportPediatrics2020
Prenatal Repair of Myelomeningocele and School-age Functional Outcomes.
Trial report in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Outcomes in prenatal vs. postnatal surgery for myelomeningocele: a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Pooled it
- Pooled it
- Reproductive outcomes following open maternal-fetal surgery for myelomeningocele closure: analysis of MOMS trial participants.American journal of obstetrics & gynecology MFM · 2025Trial
- Ventricle Width and Cerebrospinal Fluid Diversion Rate after Open Fetal Spina Bifida Repair: A 4-Year Follow-Up.Fetal diagnosis and therapy · 2026Article
- In vitro evaluation of a decellularized human fetal skin-derived scaffold repopulated with human amniotic fluid stem cells for potential application in myelomeningocele repair.Scientific reports · 2026Article
- Quality of life in children with myelomeningocele undergoing intrauterine repair and postnatal surgery.The journal of spinal cord medicine · 2026Article
- A Single-Center Clinical Experience with Fully Percutaneous, Minimally Invasive Fetoscopic Surgery for Spina Bifida Aperta.Biomedicines · 2025Article
- Comparison of open fetal, fetoscopic and postnatal surgical repair for open spina bifida: decision analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- Maternal-fetal surgery for myelomeningocele longitudinal follow-up model: Mitigation of care fragmentation through care coordination and outcomes reporting.Journal of pediatric rehabilitation medicine · 2025Review
- Factors influencing the perception of shunt devices in children after ventriculo-peritoneal shunts.BMC neurology · 2025Article
- Implementation ofAJOG global reports · 2025Article
- Fetal surgery for myelomeningocele: initial results of a tertiary public hospital.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Prenatal Spina Bifida Repair: A Survey of Current Practice in the United States.Plastic and reconstructive surgery. Global open · 2024Article
- Article
- Safety and efficacy of human umbilical cord-derived mesenchymal stromal cells in fetal ovine myelomeningocele repair.Stem cell research & therapy · 2024Article
- Contextual predictors of self-management and independence trajectories in adolescents and young adults with spina bifida.Developmental medicine and child neurology · 2024Article
- Precarious hope: Ethical considerations for offering experimental fetal therapies outside of research after initial studies in humans.Prenatal diagnosis · 2024Article
- The impact of a biocellulose-based repair of fetal open spina bifida on the need to untether the cord: is it time to unify techniques for prenatal repair?Einstein (Sao Paulo, Brazil) · 2024Observational
- Long-Term Imaging Follow-up from the Management of Myelomeningocele Study.AJNR. American journal of neuroradiology · 2023Article
- What has changed in pediatric neurosurgical care in spina bifida? A 30-year UAB/Children's of Alabama observational overview.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe Management of Myelomeningocele Study (MOMS), a randomized trial of prenatal versus postnatal repair for myelomeningocele, found that prenatal surgery resulted in reduced hindbrain herniation and need for shunt diversion at 12 months of age and better motor function at 30 months. In this study, we compared adaptive behavior and other outcomes at school age (5.9-10.3 years) between prenatal versus postnatal surgery groups.
methodsFollow-up cohort study of 161 children enrolled in MOMS. Assessments included neuropsychological and physical evaluations. Children were evaluated at a MOMS center or at a home visit by trained blinded examiners.
resultsThe Vineland composite score was not different between surgery groups (89.0 ± 9.6 in the prenatal group versus 87.5 ± 12.0 in the postnatal group;
conclusionsThere was no significant difference between surgery groups in overall adaptive behavior. Long-term benefits of prenatal surgery included improved mobility and independent functioning and fewer surgeries for shunt placement and revision, with no strong evidence of improved cognitive functioning.
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