Evidence map›Paper›PMID 31980301›Full record

ReviewTrends in biotechnology2020

Enabling Technologies for Personalized and Precision Medicine.

Dean Ho, Stephen R Quake, Edward R B McCabe, Wee Joo Chng, Edward K Chow, Xianting Ding, Bruce D Gelb, Geoffrey S Ginsburg, Jason Hassenstab, Chih-Ming Ho and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  10. Trial
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  12. Review
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  15. A Geometrically Transient Platform for Bioelectronic Implants.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
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130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Dean HoThe N.1 Institute for Health (N.1), National University of Singapore, Singapore; The Institute for Digital Medicine (WisDM), National University of Singapore, Singapore; Department of Biomedical Engineering, NUS Engineering, National University of Singapore, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: biedh@nus.edu.sg.
Stephen R QuakeDepartment of Bioengineering, Stanford University, CA, USA; Department of Applied Physics, Stanford University, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Edward R B McCabeMarch of Dimes Foundation, New York, USA. Electronic address: emccabe@mednet.ucla.edu.
Wee Joo ChngDepartment of Haematology and Oncology, National University Cancer Institute, National University Health System, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Edward K ChowDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Xianting DingInstitute for Personalized Medicine, Shanghai Jiao Tong University, Shanghai, China.
Bruce D GelbMindich Child Health and Development Institute, Departments of Pediatrics and Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NY, USA.
Geoffrey S GinsburgCenter for Applied Genomics and Precision Medicine, Duke University, NC, USA.
Jason HassenstabDepartment of Neurology, Washington University in St. Louis, MO, USA; Psychological & Brain Sciences, Washington University in St. Louis, MO, USA.
Chih-Ming HoDepartment of Mechanical Engineering, University of California, Los Angeles, CA, USA.
William C MobleyDepartment of Neurosciences, University of California, San Diego, CA, USA.
Garry P NolanDepartment of Microbiology & Immunology, Stanford University, CA, USA.
Steven T RosenComprehensive Cancer Center and Beckman Research Institute, City of Hope, CA, USA.
Patrick TanDuke-NUS Medical School, National University of Singapore, Singapore.
Yun YenCollege of Medical Technology, Center of Cancer Translational Research, Taipei Cancer Center of Taipei Medical University, Taipei, Taiwan.
Ali ZarrinparDepartment of Surgery, Division of Transplantation & Hepatobiliary Surgery, University of Florida, FL, USA.

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
The Cellular Response to Elafin in PAHP01HL108797 · NHLBI · STANFORD UNIVERSITY · PI RABINOVITCH, MARLENE · 2011 to 2021
$19.7M
Ischemia-reperfusion injury in liver transplantationK08DK113244 · NIDDK · UNIVERSITY OF FLORIDA · PI ZARRINPAR, ALI · 2017 to 2021
$814k
NHLBI NIH HHS P01 HL108797NIAID NIH HHS U19 AI057229NIDDK NIH HHS K08 DK113244
6 · The paper itself

Abstract

Individualizing patient treatment is a core objective of the medical field. Reaching this objective has been elusive owing to the complex set of factors contributing to both disease and health; many factors, from genes to proteins, remain unknown in their role in human physiology. Accurately diagnosing, monitoring, and treating disorders requires advances in biomarker discovery, the subsequent development of accurate signatures that correspond with dynamic disease states, as well as therapeutic interventions that can be continuously optimized and modulated for dose and drug selection. This work highlights key breakthroughs in the development of enabling technologies that further the goal of personalized and precision medicine, and remaining challenges that, when addressed, may forge unprecedented capabilities in realizing truly individualized patient care.

Indexed as

DiagnosisArtificial IntelligenceBiomarkersHumansPrecision MedicineTherapeuticsBiomarkersartificial intelligenceclinical trialsdiagnosticspersonalized medicineprecision medicinetherapeutics

Identifiers

PMID31980301
PMCPMC7924935

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.