Evidence map›Paper›PMID 31979375›Full record

ArticleMicroorganisms2020

Impact of Chronic Obstructive Pulmonary Disease on Incidence, Microbiology and Outcome of Ventilator-Associated Lower Respiratory Tract Infections.

Anahita Rouzé, Pauline Boddaert, Ignacio Martin-Loeches, Pedro Povoa, Alejandro Rodriguez, Nassima Ramdane, Jorge Salluh, Marion Houard, Saad Nseir

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Anahita RouzéCentre Hospitalier Universitaire Lille, Critical Care Center, F-59000 Lille, France.
Pauline BoddaertCentre Hospitalier Universitaire Lille, Critical Care Center, F-59000 Lille, France.
Ignacio Martin-LoechesDepartment of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, St James Street, Dublin 8, D08 NHY1 Dublin, Ireland.
Pedro PovoaNova Medical School, New University of Lisbon, 1099-085 Lisbon, Portugal.
Alejandro RodriguezICU, Hospital Universitari de Tarragona Joan XXIII, 43005 Tarragona, Spain.
Nassima RamdaneCentre Hospitalier Universitaire Lille, University of Lille, EA 2694-Santé Publique, Epidémiologie et Qualité des Soins, Département de Biostatistiques, F-59000 Lille, France.
Jorge SalluhInstitute for Research and Education, D'Or, Rio de Janeiro 22281-100, Brazil.
Marion HouardCentre Hospitalier Universitaire Lille, Critical Care Center, F-59000 Lille, France.
Saad NseirCentre Hospitalier Universitaire Lille, Critical Care Center, F-59000 Lille, France.
Université de Lille · FRCentre Hospitalier Universitaire de Lille · FRD’Or Institute for Research and Education · BRHospital Universitari Joan XXIII de Tarragona · ESSt. James's Hospital · IEUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the impact of chronic obstructive pulmonary disease (COPD) on incidence, microbiology, and outcomes of ventilator-associated lower respiratory tract infections (VA-LRTI).

methodsPlanned ancillary analysis of TAVeM study, including 2960 consecutive adult patients who received invasive mechanical ventilation (MV) > 48 h. COPD patients (n = 494) were compared to non-COPD patients (n = 2466). The diagnosis of ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP) was based on clinical, radiological and quantitative microbiological criteria.

resultsNo significant difference was found in VAP (12% versus 13%, p = 0.931), or VAT incidence (13% versus 10%, p = 0.093) between COPD and non-COPD patients. Among patients with VA-LRTI, Escherichia coli and Stenotrophomonas maltophilia were significantly more frequent in COPD patients as compared with non-COPD patients. However, COPD had no significant impact on multidrug-resistant bacteria incidence. Appropriate antibiotic treatment was not significantly associated with progression from VAT to VAP among COPD patients who developed VAT, unlike non-COPD patients. Among COPD patients, patients who developed VAT or VAP had significantly longer MV duration (17 days (9-30) or 15 (8-27) versus 7 (4-12), p < 0.001) and intensive care unit (ICU) length of stay (24 (17-39) or 21 (14-40) versus 12 (8-19), p < 0.001) than patients without VA-LRTI. ICU mortality was also higher in COPD patients who developed VAP (44%), but not VAT(38%), as compared to no VA-LRTI (26%, p = 0.006). These worse outcomes associated with VA-LRTI were similar among non-COPD patients.

conclusionsCOPD had no significant impact on incidence or outcomes of patients who developed VAP or VAT.

Indexed as

chronic obstructive pulmonary diseaseintensive carelower respiratory tract infectionsmechanical ventilationpneumoniatracheobronchitisventilator-associated

Identifiers

PMID31979375
PMCPMC7074722
OpenAlexW3002326880

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.