ArticleMarine drugs2020
Design of Fungal Co-Cultivation Based on Comparative Metabolomics and Bioactivity for Discovery of Marine Fungal Agrochemicals.
Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A coculture system of Epicoccum nigrum with Mucor racemosus induces red pigment biosynthesis in vinegar mash.Applied microbiology and biotechnology · 2026Article
- Pathogen-induced modulation of the volatile metabolome of Hanseniaspora uvarum LE-1 and its role in post-harvest disease suppression.World journal of microbiology & biotechnology · 2026Article
- Influence of culture conditions on metabolite diversity inFrontiers in microbiology · 2026Article
- Unlocking the biotechnological potential of Baltic microorganisms.Frontiers in microbiology · 2025Review
- Biodiversity of microorganisms in the Baltic Sea: the power of novel methods in the identification of marine microbes.FEMS microbiology reviews · 2024Review
- Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689.Natural products and bioprospecting · 2024Article
- The Impact of the Culture Regime on the Metabolome and Anti-Phytopathogenic Activity of Marine Fungal Co-Cultures.Marine drugs · 2024Article
- Article
- Exploring Diverse Bioactive Secondary Metabolites from Marine Microorganisms Using Co-Culture Strategy.Molecules (Basel, Switzerland) · 2023Review
- Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle.International journal of molecular sciences · 2023Review
- The Potential Use of Fungal Co-Culture Strategy for Discovery of New Secondary Metabolites.Microorganisms · 2023Review
- Metabolomics on the study of marine organisms.Metabolomics : Official journal of the Metabolomic Society · 2022Review
- Induction of Isochromanones by Co-Cultivation of the Marine FungusInternational journal of molecular sciences · 2022Article
- Recent Findings in Azaphilone Pigments.Journal of fungi (Basel, Switzerland) · 2021Review
- Elicitation of Antimicrobial Active Compounds byMicroorganisms · 2021Article
- New Enantiomers of a Nor-Bisabolane Derivative and Two New Phthalides Produced by the Marine-Derived FungusFrontiers in microbiology · 2021Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial co-cultivation is employed for awakening silent biosynthetic gene clusters (BGCs) to enhance chemical diversity. However, the selection of appropriate partners for co-cultivation remains a challenge. Furthermore, competitive interactions involving the suppression of BGCs or upregulation of known, functional metabolite(s) during co-cultivation efforts is also common. Herein, we performed an alternative approach for targeted selection of the best co-cultivation pair. Eight marine sediment-derived fungi were classified as strong or weak, based on their anti-phytopathogenic potency. The fungi were co-cultured systematically and analyzed for their chemical profiles and anti-phytopathogenic activity. Based on enhanced bioactivity and a significantly different metabolite profile including the appearance of a co-culture specific cluster, the co-culture of
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