Evidence map›Paper›PMID 31979182›Full record

ArticlePlants (Basel, Switzerland)2020

Phenolic Profile, Toxicity, Enzyme Inhibition, In Silico Studies, and Antioxidant Properties of Cakile maritima Scop. (Brassicaceae) from Southern Portugal.

Chloé Placines, Viana Castañeda-Loaiza, Maria João Rodrigues, Catarina G Pereira, Azzurra Stefanucci, Adriano Mollica, Gokhan Zengin, Eulogio J Llorent-Martínez, Paula C Castilho, And Luísa Custódio

Open access · goldAbstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Valorisation of the HalophyteFoods (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Salinity tolerance in the halophyte speciesFrontiers in plant science · 2025
    Article
  6. Article
  7. Article
  8. Plant Extracts as Skin Care and Therapeutic Agents.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. LC-MS Based Analysis and Biological Properties ofAntioxidants (Basel, Switzerland) · 2021
    Article
  13. Salinity Stress Alters the Secondary Metabolic Profile ofInternational journal of molecular sciences · 2021
    Article
  14. Polysaccharides ofEvidence-based complementary and alternative medicine : eCAM · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Chloé PlacinesCentre of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal.
Viana Castañeda-LoaizaCentre of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal.
Maria João RodriguesCentre of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal.
Catarina G PereiraCentre of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal.
Azzurra StefanucciDepartment of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Adriano MollicaDepartment of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy.
Gokhan ZenginDepartment of Biology, Science Faculty, Selcuk University, Campus, 42250 Konya, Turkey.
Eulogio J Llorent-MartínezDepartment of Physical and Analytical Chemistry, Faculty of Experimental Sciences, University of Jaén, Campus Las Lagunillas, E-23071 Jaén, Spain.
Paula C CastilhoCQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105, Funchal, Portugal.
And Luísa CustódioCentre of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal.
University of Algarve · PTUniversity of Chieti-Pescara · ITSelçuk University · TRUniversidad de Jaén · ESUniversidade da Madeira · PT

Funding

Fundação para a Ciência e a Tecnologia ALG-01-0145-FEDER-028876Fundação para a Ciência e a Tecnologia CCMAR/Multi/04326/2019Fundação para a Ciência e a Tecnologia CEECIND/00425/2017Fundação para a Ciência e a Tecnologia SFRH/BD/116604/2016Fundação para a Ciência e a Tecnologia UID/DTP/04138/2019
6 · The paper itself

Abstract

Cakile maritima Scop. (sea rocket) is an edible halophyte plant with several ethnomedicinal uses. This work reports the chemical profile and bioactivities of food grade extracts from sea rocket organs. Toxicity was determined on mammalian cells, and phenolic profiling and the quantitation of the main metabolites were made by high-performance liquid chromatography coupled to mass spectrometry (HPLC-MS). Enzymatic inhibition was determined towards acetyl- and butyrylcholinesterase (AChE, BuChE), α-glucosidase, α-amylase, and tyrosinase. Docking studies were performed to tyrosinase, on the major metabolites, and samples were tested for antioxidant properties. Extracts were not toxic, were constituted mainly by flavonoids, and some compounds (roseoside and oleuropein) are here described for the first time in the species. The aerial organs' ethanol extract had relevant activity towards 2,2-diphenyl-1-picrylhydrazyl [DPPH, half maximal inhibitory concentration (IC

Indexed as

bioactive plant-derived productssalt tolerant plantstyrosinase inhibitors

Identifiers

PMID31979182
PMCPMC7076647
OpenAlexW3002847670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.