ReviewMetabolites2020
Current Practice in Untargeted Human Milk Metabolomics.
Review in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05646940 (Fact-based Nutrition for Infants and Lactating Mothers - The NUTRISHIELD Study), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fact-based Nutrition for Infants and Lactating Mothers - The NUTRISHIELD Study
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human milk composition and infant anthropometrics: overview of a systematic review with clinical and research implications.International breastfeeding journal · 2024Pooled it
- Milk metabolite composition of a semi-captive population of Asian elephants.Royal Society open science · 2024Article
- Untargeted metabolomic analysis of human milk from healthy mothers reveals drivers of metabolite variability.Scientific reports · 2024Article
- Children with Hirschsprung disease exhibited alterations in host-microbial co-metabolism after pull-through operation.Pediatric surgery international · 2024Article
- Multiplatform untargeted metabolomics.Magnetic resonance in chemistry : MRC · 2023Review
- Metabolomic Diversity of Human Milk Cells over the Course of Lactation-A Preliminary Study.Nutrients · 2023Article
- Perspective: Human Milk Composition and Related Data for National Health and Nutrition Monitoring and Related Research.Advances in nutrition (Bethesda, Md.) · 2022Article
- Article
- NMR Metabonomic Profile of Preterm Human Milk in the First Month of Lactation: From Extreme to Moderate Prematurity.Foods (Basel, Switzerland) · 2022Article
- The need to study human milk as a biological system.The American journal of clinical nutrition · 2021Article
- The Metabolomic Analysis of Human Milk Offers Unique Insights into Potential Child Health Benefits.Current nutrition reports · 2021Review
- Dynamic Associations of Milk Components With the Infant Gut Microbiome and Fecal Metabolites in a Mother-Infant Model by Microbiome, NMR Metabolomic, and Time-Series Clustering Analyses.Frontiers in nutrition · 2021Article
- Impact of Storage Conditions on the Breast Milk Peptidome.Nutrients · 2020Article
- The Milk Metabolome of Non-secretor and Lewis Negative Mothers.Frontiers in nutrition · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Human milk (HM) is considered the gold standard for infant nutrition. HM contains macro- and micronutrients, as well as a range of bioactive compounds (hormones, growth factors, cell debris, etc.). The analysis of the complex and dynamic composition of HM has been a permanent challenge for researchers. The use of novel, cutting-edge techniques involving different metabolomics platforms has permitted to expand knowledge on the variable composition of HM. This review aims to present the state-of-the-art in untargeted metabolomic studies of HM, with emphasis on sampling, extraction and analysis steps. Workflows available from the literature have been critically revised and compared, including a comprehensive assessment of the achievable metabolome coverage. Based on the scientific evidence available, recommendations for future untargeted HM metabolomics studies are included.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.