ArticleJournal of neural engineering2020
High resolution transcranial acoustoelectric imaging of current densities from a directional deep brain stimulator.
Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biological current source imaging method based on acoustoelectric effect: A systematic review.Frontiers in neuroscience · 2022Pooled it
- Hadamard-encoded synthetic beamforming for high frame rate acoustoelectric current source imaging.Ultrasonics · 2026Article
- A Precise Focusing Simulation Platform for Transcranial Acoustoelectric Brain Imaging.Sensors (Basel, Switzerland) · 2026Article
- Neuronavigation-Guided Transcranial Acoustoelectric Brain Imaging: A New Modality for High Resolution Electrical Brain Mapping.IEEE transactions on bio-medical engineering · 2025Article
- Acoustoelectric Time-Reversal for Ultrasound Phase-Aberration Correction.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Current Source Density Imaging Using Regularized Inversion of Acoustoelectric Signals.IEEE transactions on medical imaging · 2023Article
- Acoustoelectric brain imaging with different conductivities and acoustic distributions.Frontiers in physiology · 2023Article
- In vivo acoustoelectric imaging for high-resolution visualization of cardiac electric spatiotemporal dynamics.Applied optics · 2020Article
- Recent advances in bioelectronics chemistry.Chemical Society reviews · 2020Review
- Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy.Journal of neural engineering · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveNew innovations in deep brain stimulation (DBS) enable directional current steering-allowing more precise electrical stimulation of the targeted brain structures for Parkinson's disease, essential tremor and other neurological disorders. While intra-operative navigation through MRI or CT approaches millimeter accuracy for placing the DBS leads, no existing modality provides feedback of the currents as they spread from the contacts through the brain tissue. In this study, we investigate transcranial acoustoelectric imaging (tAEI) as a new modality to non-invasively image and characterize current produced from a directional DBS lead. tAEI uses ultrasound (US) to modulate tissue resistivity to generate detectable voltage signals proportional to the local currents. APPROACH: An 8-channel directional DBS lead (Infinity 6172ANS, Abbott Inc) was inserted inside three adult human skulls submerged in 0.9% NaCl. A 2.5 MHz linear array delivered US pulses through the transtemporal window and focused near the contacts on the lead, while a custom amplifier and acquisition system recorded the acoustoelectric (AE) interaction used to generate images. MAIN
resultstAEI detected monopolar current with stimulation pulses as short as 100 µs with an SNR ranging from 10-27 dB when using safe US pressure (mechanical indices <0.78) and injected current of ~2 mA peak amplitude. Adjacent contacts were discernable along the length and within each ring of the lead with a mean radial separation between contacts of 2.10 and 1.34 mm, respectively. SIGNIFICANCE: These results demonstrate the feasibility of tAEI for high resolution mapping of directional DBS currents using clinically-relevant stimulation parameters. This new modality may improve the accuracy for placing the DBS leads, guide calibration and programming, and monitor long-term performance of DBS for treatment of Parkinson's disease.
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