Evidence map›Paper›PMID 31978340›Full record

ArticleCell2020

A Single Transcription Factor Drives Toxoplasma gondii Differentiation.

Joshua A Kochanowsky, Anita A Koshy

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joshua A KochanowskyDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.
Anita A KoshyDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA; Department of Neurology, University of Arizona, Tucson, Arizona, USA; Bio5 Institute, University of Arizona, Tucson, Arizona, USA. Electronic address: akoshy@email.arizona.edu.
University of Arizona · US

Funding

Defining neuron-Toxoplasma gondii interactions that mediate CNS toxoplasmosisR01NS095994 · NINDS · UNIVERSITY OF ARIZONA · PI KOSHY, ANITA · 2016 to 2020
$2.0M
ROP16's role in Toxoplasma gondii strain-specific encystmentR21AI147756 · NIAID · UNIVERSITY OF ARIZONA · PI KOSHY, ANITA · 2019 to 2020
$409k
NIAID NIH HHS R21 AI147756NINDS NIH HHS R01 NS095994
6 · The paper itself

Abstract

Microbes that cause persistent infections (e.g., herpes viruses) do so by switching from fast-growing lytic states to slow-growing latent states. Waldman et al. have identified a single transcription factor that governs the switch between the lytic and latent forms of Toxoplasma gondii, a parasite that causes a persistent brain infection.

Indexed as

ToxoplasmaBrainCell DifferentiationGene Expression RegulationTranscription FactorsTranscription Factors

Identifiers

PMID31978340
OpenAlexW3001068690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.