Evidence map›Paper›PMID 31978271›Full record

ArticleChild: care, health and development2020

Neonatal jaundice and developmental impairment among infants in Kilifi, Kenya.

Dorcas N Magai, Michael Mwaniki, Amina Abubakar, Shebe Mohammed, Anne L Gordon, Raphael Kalu, Paul Mwangi, Hans M Koot, Charles R Newton

Open access · hybridAbstract read
In one paragraph

Article in Child: care, health and development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. The outcomes of an audiological management programme for neonates with hyperbilirubinaemia.The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Dorcas N MagaiCentre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya.ORCID 0000-0002-1889-7552
Michael MwanikiCentre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya.
Amina AbubakarCentre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya.ORCID 0000-0002-3686-7904
Shebe MohammedCentre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya.
Anne L GordonFaculty of Life Sciences and Medicine, King's College London, London, UK.
Raphael KaluCentre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya.
Paul MwangiCentre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya.
Hans M KootDepartment of Clinical, Neuro- and Developmental Psychology, Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-9643-2363
Charles R NewtonCentre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya.ORCID 0000-0002-6999-5507
Kenya Medical Research Institute · KEPwani University · KEKing's College London · GBVrije Universiteit Amsterdam · NL

Funding

Medical Research Council MR/N022157/1Wellcome TrustWellcome Trust 077092/B/05/ZWellcome Trust 107769/Z/10/Z
6 · The paper itself

Abstract

backgroundNeonatal jaundice (NNJ) is common in sub-Saharan Africa (SSA), and it is associated with sepsis. Despite the high incidence, little has been documented about developmental impairments associated with NNJ in SSA. In particular, it is not clear if sepsis is associated with greater impairment following NNJ.

methodsWe followed up 169 participants aged 12 months (57 cases and 112 controls) within the Kilifi Health Demographic Surveillance System. The diagnosis of NNJ was based on clinical laboratory measurement of total serum bilirubin on admission, whereas the developmental outcomes were assessed using the Developmental Milestones Checklist and Kilifi Development Inventory.

resultsThere were significant differences between the cases and controls in all developmental domains. Cases scored lower in language functioning (mean [M] = 6.5, standard deviation [SD] = 4.3 vs. M = 8.9, SD = 4.6; p < .001); psychomotor functioning (Mdn = 23, interquartile range [IQR] = 17-34 vs. Mdn = 31.0, IQR = 22.0-44.0; Mann-Whitney U = 4,122, p = .002); and socio-emotional functioning ([Mdn = 30.0, IQR = 27.0-33.0 vs. Mdn = 34.0, IQR = 30.0-37.0], Mann-Whitney U = 4,289, p < .001). There was no evidence of association between sepsis and psychomotor (r

conclusionsNNJ is associated with developmental impairments in the early childhood years; however, NNJ associated with sepsis does not lead to more severe impairment. Prenatal and postnatal care services are needed to reduce the negative impact of NNJ for children from low resourced settings.

Indexed as

Case-Control StudiesDevelopmental DisabilitiesFemaleHumansInfantInfant, NewbornJaundice, NeonatalKenyaLongitudinal StudiesMaleRisk FactorsSepsischild developmentchild disabilitychildhood disabilitydelayed languagedeveloping countriesdevelopmental delay

Identifiers

PMID31978271
PMCPMC7187241
OpenAlexW3002663297

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.