ArticlePloS one2020
Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Impact of educational interventions provided to patients with a central venous catheter and their informal caregivers: a systematic review.Antimicrobial resistance and infection control · 2025Pooled it
- Risk factors of catheter- associated bloodstream infection: Systematic review and meta-analysis.PloS one · 2023Pooled it
- Pathogen-specific clinical and inflammatory phenotypes in pediatric catheter-related infections.European journal of pediatrics · 2026Article
- Missing data, missed risks: complications and documentation gaps of central venous access devices in pediatric oncology.BMC pediatrics · 2026Article
- Article
- Hydrochloric Acid Lock Therapy for Catheter-Related Bloodstream Infections: In Vitro Antimicrobial Activity and Catheter Material Compatibility.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- Clinical and microbiological characteristics of polymicrobial bloodstream infections in hematologic malignancy patients: a cross-sectional study.BMC infectious diseases · 2026Article
- Incidence and risk factors for hospital-attributable central line-associated bloodstream infections in adult inpatients in a tertiary hospital.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Metagenomic and Phenotypic Insights Into Biofilm-Forming Pathogens in Patients With Nosocomial Sepsis.BioMed research international · 2026Article
- Development and validation of a nomogram for predicting PICC catheter-related bloodstream infection among patients with hematologic malignancies.BMC infectious diseases · 2025Article
- Review
- Can We Lower the Burden of Antimicrobial Resistance (AMR) in Heavily Immunocompromised Patients? A Narrative Review and Call to Action.Infectious diseases and therapy · 2025Review
- Effectiveness of Vascular Catheter Removal Versus Retention in Non-ICU Patients with CRBSI or CABSI in Retrospective, Single-Center Study.Microorganisms · 2025Article
- Prevalence of central line-associated bloodstream infections in patients with cancer and subgroup analysis using propensity score matching: A nationwide multicenter study in Italy.International journal of nursing sciences · 2025Article
- Factors Affecting the Direct and Indirect Performance of Infection Control for Centrally Inserted Central Catheters Among ICU Nurses.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Antibiotic lock therapy for the treatment of peripherally inserted central venous catheter-related bloodstream infection in patients with hematological malignancies: a single center retrospective study.Annals of hematology · 2025Article
- Trends in the epidemiology of intravascular device-associated bacteremia among French hematology patients: insights from the SPIADI prospective multicenter study, 2020-2024.Annals of hematology · 2025Article
- Treatment response evaluation in anFrontiers in pediatrics · 2025Article
- The Extra Length of Stay, Costs, and Mortality Associated With Healthcare-Associated Infections: A Case-Control Study.Health science reports · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-implanted central vascular catheters (CVC) are frequently required for therapy in hospitalized patients with hematological malignancies or solid tumors. However, CVCs may represent a source for bloodstream infections (central line-associated bloodstream infections, CLABSI) and, thus, may increase morbidity and mortality of these patients. A retrospective cohort study over 3 years was performed. Risk factors were determined and evaluated by a multivariable logistic regression analysis. Healthcare costs of CLABSI were analyzed in a matched case-control study. In total 610 patients got included with a CLABSI incidence of 10.6 cases per 1,000 CVC days. The use of more than one CVC per case, CVC insertion for conditioning for stem cell transplantation, acute myeloid leukemia, leukocytopenia (≤ 1000/μL), carbapenem therapy and pulmonary diseases were independent risk factors for CLABSI. Hospital costs directly attributed to the onset of CLABSI were 8,810 € per case. CLABSI had a significant impact on the overall healthcare costs. Knowledge about risk factors and infection control measures for CLABSI prevention is crucial for best clinical practice.
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