Evidence map›Paper›PMID 31977917›Full record

Observational studyMedicine2020

Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.

Weifeng Guo, Huiqing Zeng, Jinyang Zheng, Yueming He, Xibin Zhuang, Jinghuang Cai, Hong Huang, Hongbo Huang, Meng Xu

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Weifeng GuoDepartment of Respiratory Medicine, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou.
Huiqing ZengFujian Medical University Union Hospital, Fuzhou.
Jinyang ZhengDepartment of Pathology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, China.
Yueming HeDepartment of Respiratory Medicine, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou.
Xibin ZhuangDepartment of Respiratory Medicine, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou.
Jinghuang CaiDepartment of Respiratory Medicine, Zhongshan Hospital Affiliated to Xiamen University, Xiamen.
Hong HuangDepartment of Respiratory Medicine, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou.
Hongbo HuangDepartment of Respiratory Medicine, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou.
Meng XuDepartment of Respiratory Medicine, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou.
Fujian Medical University · CNUnion Hospital · CNZhongshan Hospital of Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the expression of Kif18A in cancerous and paracancerous tissues from 100 patients with nonsmall cell lung cancer (NSCLC).This was a prospective study of 100 patients with pathologically confirmed NSCLC (adenocarcinoma and squamous cell carcinoma [SCC], n = 50/group) that were operated at the Quanzhou First Hospital Affiliated to Fujian Medical University between June 2015 and December 2016. Kif18A protein expression in cancerous and paracancerous normal tissues was detected by western blot and immunohistochemistry.The expression of the Kif18A protein was higher in adenocarcinoma and SCC tissues than in the corresponding paracancerous normal tissues. The expression of the Kif18A protein was higher in highly differentiated tumors, in patients with lymph node metastasis (vs no lymph node metastasis), adenocarcinoma, and in stage III NSCLC. There were no associations between Kif18A expression and age, gender, and pathologic type.The expression of the Kif18A protein by immunohistochemistry was higher in NSCLC tissues than in normal tissues, and was associated with tumor differentiation, lymph node metastasis, and TNM staging. These results could provide a theoretical basis for novel molecular targeted therapies against NSCLC.

Indexed as

KinesinsAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellFemaleGene Expression Regulation, NeoplasticHumansLung NeoplasmsLymphatic MetastasisMaleMiddle AgedProspective StudiesBiomarkers, TumorKIF18A protein, humanKinesins

Identifiers

PMID31977917
PMCPMC7004722
OpenAlexW3001938621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.