Evidence map›Paper›PMID 31977730›Full record

ArticleCornea2020

Limbal Stem Cell Deficiency After Glaucoma Surgery.

Yuzhao Sun, Madeline Yung, Linying Huang, Chihong Tseng, Sophie X Deng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cornea, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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  8. Limbal stem cell diseases.Experimental eye research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Yuzhao SunCornea Division, Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA.
Madeline YungCornea Division, Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA.
Linying HuangCornea Division, Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA.
Chihong TsengDepartment of Medicine, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Sophie X DengCornea Division, Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA.
Southern California Eye Institute · USChina Medical University · CNUniversity of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, DAVID S WILLIAMS · 1985 to 2026
$16.8M
Ex Vivo Expansion of Human Limbal Stem Cells for TransplantationR01EY021797 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sophie Deng · 2012 to 2026
$5.1M
Development of small-molecule Wnt mimetics for corneal epithelial cell regenerationR01EY028557 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DENG, SOPHIE, ZHENG, JIE J. · 2018 to 2021
$2.0M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY021797NEI NIH HHS R01 EY028557
6 · The paper itself

Abstract

purposeTo characterize the clinical presentation of limbal stem cell deficiency (LSCD) associated with glaucoma surgeries.

methodsThis is a retrospective cross-sectional study of patients with LSCD and glaucoma who presented to the Stein Eye Institute at the University of California, Los Angeles, between 2009 and 2018. Patients who underwent trabeculectomy and/or aqueous shunt surgery were included. The severity of LSCD was staged using global consensus guidelines and a clinical scoring system, and basal epithelial cell density was measured by in vivo confocal microscopy. Anatomic locations of glaucoma and non-glaucoma surgeries, locations of LSCD, and severity of LSCD were compared.

resultsFifty-one eyes of 41 patients with LSCD associated with glaucoma surgery were included in this study. LSCD in these patients uniquely featured sectoral replacement of corneal epithelium by conjunctival epithelium, without corneal neovascularization or pannus. The sites of glaucoma surgery strongly correlated with the locations of LSCD (P = 0.002). There was a trend toward increased severity of LSCD in eyes with 2 or more glaucoma surgeries as compared to eyes with 1 glaucoma surgery, although the difference did not reach statistical significance (P = 0.3). Use of topical glaucoma medications correlated with LSCD severity, while the impact of antimetabolites did not reach statistical significance. The location of glaucoma drainage surgery is correlated with the location of LSCD.

conclusionsLSCD associated with glaucoma surgery has clinical features distinct from LSCD resulting from other etiologies. Further study is required to delineate the full impact of glaucoma surgery on limbal stem cell function and survival.

Indexed as

Postoperative ComplicationsAgedCell CountCorneal DiseasesCross-Sectional StudiesFemaleFiltering SurgeryGlaucomaHumansLimbus CorneaeMaleMicroscopy, ConfocalRetrospective Studies

Identifiers

PMID31977730
PMCPMC8018231
OpenAlexW3001318753

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.