Evidence map›Paper›PMID 31977241›Full record

ArticleThe British journal of radiology2020

Assessment of robustness against setup uncertainties using probabilistic scenarios in lung cancer: a comparison of proton with photon therapy.

Suliana Teoh, Ben George, Francesca Fiorini, Katherine A Vallis, Frank Van den Heuvel

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Proton therapy special feature: introductory editorial.The British journal of radiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Suliana TeohCRUK and MRC Oxford Institute for Radiation Oncology, Old Road Campus Research Building, Off Roosevelt Drive, University of Oxford, Oxford, OX3 7DQ, UK.ORCID http://orcid.org/0000-0002-5456-9273
Ben GeorgeCRUK and MRC Oxford Institute for Radiation Oncology, Old Road Campus Research Building, Off Roosevelt Drive, University of Oxford, Oxford, OX3 7DQ, UK.
Francesca FioriniCRUK and MRC Oxford Institute for Radiation Oncology, Old Road Campus Research Building, Off Roosevelt Drive, University of Oxford, Oxford, OX3 7DQ, UK.
Katherine A VallisCRUK and MRC Oxford Institute for Radiation Oncology, Old Road Campus Research Building, Off Roosevelt Drive, University of Oxford, Oxford, OX3 7DQ, UK.
Frank Van den HeuvelCRUK and MRC Oxford Institute for Radiation Oncology, Old Road Campus Research Building, Off Roosevelt Drive, University of Oxford, Oxford, OX3 7DQ, UK.
University of Oxford · GB

Funding

Cancer Research UK 21993Cancer Research UK 22906Cancer Research UK 28736
6 · The paper itself

Abstract

objectiveWe compared the sensitivity of intensity modulated proton therapy (IMPT) and photon volumetric modulated arc therapy (VMAT) plans to setup uncertainties in locally advanced non-small cell lung cancer (NSCLC) using probabilistic scenarios.

methodsMinimax robust (MM) and planning target volume (PTV) optimised IMPT and VMAT nominal plans were created with physical dose of 70 Gy in 35 fractions in 10 representative patients. Using population data of setup errors, a fractionated treatment course was simulated, summed (D

resultsAll D

conclusionWhen considering the whole treatment course, setup errors do not influence robustness irrespective of planning techniques used. However, on a fraction level, VMAT and MM-IMPT plans are superior compared to PTV-IMPT plans. ADVANCES IN KNOWLEDGE: Probabilistic analysis provides a fast and practical method for evaluating VMAT and IMPT plan sensitivity against setup uncertainty. VMAT and robust-optimised IMPT plans have comparable sensitivity to setup uncertainties in conventionally fractionated treatment for NSCLC.

Indexed as

Radiotherapy Setup ErrorsUncertaintyCarcinoma, Non-Small-Cell LungDose Fractionation, RadiationHumansLung NeoplasmsPhotonsProton TherapyRadiotherapy, Intensity-ModulatedReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID31977241
PMCPMC7066956
OpenAlexW3002141315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.