Evidence map›Paper›PMID 31977160›Full record

ReviewAdvanced healthcare materials2020

Vascularized Biomaterials to Study Cancer Metastasis.

Katharine R Bittner, Juan M Jiménez, Shelly R Peyton

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Recent advances in 3D models of tumor invasion.Current opinion in biomedical engineering · 2021
    Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Katharine R BittnerMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, 01003, USA.ORCID 0000-0002-6108-8056
Juan M JiménezMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, 01003, USA.
Shelly R PeytonMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA, 01003, USA.

Funding

A Synthetic Bone Marrow to Understand Breast Cancer DormancyR21CA223783 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI PEYTON, SHELLY R. · 2018 to 2019
$350k
NCI NIH HHS R21 CA223783NIH HHS R21CA223783
6 · The paper itself

Abstract

Cancer metastasis, the spread of cancer cells to distant organs, is responsible for 90% of cancer-related deaths. Cancer cells need to enter and exit circulation in order to form metastases, and the vasculature and endothelial cells are key regulators of this process. While vascularized 3D in vitro systems have been developed, few have been used to study cancer, and many lack key features of vessels that are necessary to study metastasis. This review focuses on current methods of vascularizing biomaterials for the study of cancer, and three main factors that regulate intravasation and extravasation: endothelial cell heterogeneity, hemodynamics, and the extracellular matrix of the perivascular niche.

Indexed as

Biocompatible MaterialsNeoplasmsEndothelial CellsExtracellular MatrixHumansNeoplasm MetastasisBiocompatible Materials3D printingangiogenesisendothelial cellsshear stress

Identifiers

PMID31977160
PMCPMC7899188

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.