ArticleCancer2020
Associations between nutritional factors and chemotherapy toxicity in older adults with solid tumors.
Article in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Impact of pretreatment body mass index on clinical outcomes in patients with metastatic renal cell carcinoma receiving first-line immune checkpoint inhibitor-based therapy: A systematic review and meta-analysis.Investigative and clinical urology · 2024Pooled it
- Nutritional Impairment and Quality of Life Trajectories Among Older Adults With Advanced Cancer.Journal of the American Geriatrics Society · 2025Trial
- Article
- Frontline ABVD Remains an Effective Option in Advanced-Stage Classical Hodgkin Lymphoma: Real-World Data from Turkey.Journal of clinical medicine · 2026Article
- Immune-inflammatory and nutritional status mediate the association between age and survival in older patients with nasopharyngeal carcinoma: a retrospective cohort study.BMC geriatrics · 2026Article
- Preoperative Nutritional Risk Defines Treatment Tolerance and Guides Adjuvant Immunotherapy in Resectable Esophageal Squamous Cell Carcinoma.Annals of surgical oncology · 2026Article
- Integrated assessment of developmental toxicity of antibiotic pollutants: Machine learning prediction, zebrafish validation, and network toxicology.Molecular diversity · 2026Article
- The obesity paradox effect of triglyceride-glucose-body mass index (TyG-BMI) on all-cause mortality in patients with malignant tumors: a machine learning-driven cohort study.Translational cancer research · 2026Article
- Exercise interventions remodel the aging microenvironment to improve prognosis in older patients with cancer.Frontiers in immunology · 2026Review
- Association between pre-treatment malnutrition and chemotherapy toxicity in patients with advanced or metastatic gastroenteric tumors receiving systemic therapy.Frontiers in nutrition · 2026Article
- Haematological, renal and hepatic toxicity profiles of infusional 5-fluorouracil versus capecitabine in African gastrointestinal cancer patients: a retrospective cohort study.Ecancermedicalscience · 2026Article
- Association of comorbidity burden with initial treatment allocation in older women with gynecologic cancer: a retrospective cohort study.Frontiers in medicine · 2026Article
- Development and validation of a prediction model for refeeding syndrome in ICU patients receiving mechanical ventilation and enteral nutrition support: a single-center retrospective study from China.Frontiers in medicine · 2026Article
- Article
- Dietary habits in relation to outcome and therapy-related toxicity in patients with glioblastoma - a retrospective cohort study.Journal of neuro-oncology · 2025Article
- Hypoalbuminemia and Nutritional Status in Docetaxel-Induced Erythema Multiforme: A Case Report.Cureus · 2025Article
- Prognostic Utility of Controlling Nutritional Status Score in Patients With Oral Cavity Cancer.Laryngoscope investigative otolaryngology · 2025Article
- Prognostic value of serum albumin-creatinine ratio as a biomarker in patients treated with immune checkpoint inhibitors.Immunotherapy · 2025Article
- Impact of Nutritional Changes on the Prognosis in Pancreatic Cancer Patients Underwent Curative Surgery After Neoadjuvant Chemotherapy.Nutrients · 2025Article
- Article
Corrections and comments
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Authors and funding
16 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundNutritional status can directly affect morbidity and mortality in older adults with cancer. This study evaluated the association between pretreatment body mass index (BMI), albumin level, and unintentional weight loss (UWL) in the prior 6 months and chemotherapy toxicity among older adults with solid tumors.
methodsThis was a secondary analysis of a prospective, multicenter study involving chemotherapy-treated patients 65 years old or older. Geriatric assessment, BMI, albumin level, and UWL data were collected before treatment. Multivariable logistic regression models evaluated the associations between nutritional factors and the risk of grade 3 or higher (grade 3+) chemotherapy toxicity.
resultsSeven hundred fifty patients with a median age of 72 years (range, 65-94 years) and mostly stage IV disease were enrolled. The median pretreatment BMI and albumin values were 26 kg/m
conclusionsAmong older adults with solid tumors, higher BMIs and normal albumin levels are associated with a lower risk of grade 3+ chemotherapy toxicity. Additional research is warranted to define the clinical significance of nutritional markers and to inform future interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.