Evidence map›Paper›PMID 31977031›Full record

ArticleBioinformatics (Oxford, England)2020

GSOAP: a tool for visualization of gene set over-representation analysis.

Tomas Tokar, Chiara Pastrello, Igor Jurisica

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Pathway Enrichment Analysis of Microarray Data.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tomas TokarKrembil Research Institute, UHN, 60 Leonard Avenue, Toronto, ON M5T 0S8, Canada.
Chiara PastrelloKrembil Research Institute, UHN, 60 Leonard Avenue, Toronto, ON M5T 0S8, Canada.
Igor JurisicaKrembil Research Institute, UHN, 60 Leonard Avenue, Toronto, ON M5T 0S8, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

motivationGene sets over-representation analysis (GSOA) is a common technique of enrichment analysis that measures the overlap between a gene set and selected instances (e.g. pathways). Despite its popularity, there is currently no established standard for visualization of GSOA results.

resultsHere, we propose a visual exploration of the GSOA results by showing the relationships among the enriched instances, while highlighting important instance attributes, such as significance, closeness (centrality) and clustering. AVAILABILITY AND IMPLEMENTATION: GSOAP is implemented as an R package and is available at https://github.com/tomastokar/gsoap.

Indexed as

Gene OntologySoftwareCluster AnalysisGene Expression Regulation

Identifiers

PMID31977031
PMCPMC7203738

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.