ArticleIEEE transactions on bio-medical engineering2020
A Noninvasive Ultrasound Resonance Method for Detecting Skull Induced Phase Shifts May Provide a Signal for Adaptive Focusing.
Article in IEEE transactions on bio-medical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 27 citations in OpenAlex.
- Volumetric Passive Acoustic Mapping and Cavitation Detection of Nanobubbles under Low-Frequency Insonation.ACS materials Au · 2025Article
- Device for Multifocal Delivery of Ultrasound Into Deep Brain Regions in Humans.IEEE transactions on bio-medical engineering · 2024Article
- Innovative aberration correction in ultrasound diagnostics with direct phase estimation for enhanced image quality.Physical and engineering sciences in medicine · 2023Article
- Characterization of the Targeting Accuracy of a Neuronavigation-Guided Transcranial FUS System In Vitro, In Vivo, and In Silico.IEEE transactions on bio-medical engineering · 2023Article
- Measuring sound velocity based on acoustic resonance using multiple narrow band transducers.Heliyon · 2023Article
- Spatio-Spectral Ultrasound Characterization of Reflection and Transmission Through Bone With Temperature Dependence.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Acoustic properties across the human skull.Ultrasonics · 2022Article
- Binary acoustic metasurfaces for dynamic focusing of transcranial ultrasound.Frontiers in neuroscience · 2022Article
- Article
- Implementation of a Skull-Conformal Phased Array for Transcranial Focused Ultrasound Therapy.IEEE transactions on bio-medical engineering · 2021Article
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3 authors at 2 institutions in 1 country.
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Abstract
objectiveThere may be a need to perform dynamic skull aberration corrections during the non-invasive high-intensity transcranial treatment with magnetic resonance imaging (MRI) -guided focused ultrasound in order to accurately and rapidly restore the focus in the brain.
methodsThis could possibly be accomplished by using an ultrasound-based correction method based on the skulls' thickness resonance frequencies. The focus of a 500 kHz transducer was centered in the ex vivo human skull caps at different temperatures. The pulse-echoed signals reflected from the skulls were analyzed in the frequency domain to reveal the resonance frequencies for the phase shift calculation. The accuracy was compared to both hydrophone and computed tomography (CT) based analytical methods.
resultsAround 73% of the measurements (n = 784) were in the optimal constructive interference region, with a 15° decrease in the average phase error compared to the previous study. In the best implementation, it performed approximately the same or better than the CT based analytical method currently in clinical use. Linear correlation was found between the resonance frequencies or skull induced phase shifts and the skull temperature with an average rate of -0.4 kHz/°C and 2.6 deg/°C, respectively.
conclusionThe ultrasound based resonance method has shown the feasibility of detecting heating-induced changes of skull phase shift non-invasively and accurately. SIGNIFICANCE: Since the technique can be made MRI compatible and integrated in the therapy arrays, it may enable temperature tracking and adaptive focusing during high-intensity transcranial ultrasound treatments, to prevent skull overheating and preserve the transcranial focusing integrity.
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