ArticleMetallomics : integrated biometal science2020
Changes in mammalian copper homeostasis during microbial infection.
Article in Metallomics : integrated biometal science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Tumor CTR1 Expression and Systemic Copper Dynamics Converge on a Copper Axis in High-Grade Triple-Negative Breast Cancer.Cancer research communications · 2026Article
- Iron, copper and zinc isotope ratios in malaria infection reveal signatures of the Plasmodium biology and host mice response to the infection.Communications biology · 2026Article
- Article
- GLS as a Key Cuproptosis-Related Gene in Periodontitis: Insights from Single-Cell RNA Sequencing.International dental journal · 2025Article
- Mammalian copper homeostasis: physiological roles and molecular mechanisms.Physiological reviews · 2025Review
- Molecular mechanisms and potential implications of ferroptosis, cuproptosis, and disulfidptosis in septic lung injury.Frontiers in medicine · 2025Review
- Metals at the Host-Fungal Pathogen Battleground.Annual review of microbiology · 2024Review
- Role of cuproptosis in mediating the severity of experimental malaria-associated acute lung injury/acute respiratory distress syndrome.Parasites & vectors · 2024Article
- Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems.Microbiology and molecular biology reviews : MMBR · 2024Review
- Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients.Frontiers in cellular and infection microbiology · 2024Article
- The role of manganese in morphogenesis and pathogenesis of the opportunistic fungal pathogen Candida albicans.PLoS pathogens · 2023Article
- Article
- The Aging Features of Thyrotoxicosis Mice: Malnutrition, Immunosenescence and Lipotoxicity.Frontiers in immunology · 2022Article
- Novel dithiocarbamate derivatives are effective copper-dependent antimicrobials againstFrontiers in microbiology · 2022Article
- Comparative Biophysical and Ultrastructural Analysis of Melanins Produced by Clinical Strains of Different Species From the Trichosporonaceae Family.Frontiers in microbiology · 2022Article
- Demonstration ofMicrobiology spectrum · 2021Article
- Ceruloplasmin as a source of Cu for a fungal pathogen.Journal of inorganic biochemistry · 2021Article
- Copper Availability Influences the Transcriptomic Response of Candida albicans to Fluconazole Stress.G3 (Bethesda, Md.) · 2021Article
- Article
- Expanded role of the Cu-sensing transcription factor Mac1p in Candida albicans.Molecular microbiology · 2020Article
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Abstract
Animals carefully control homeostasis of Cu, a metal that is both potentially toxic and an essential nutrient. During infection, various shifts in Cu homeostasis can ensue. In mice infected with Candida albicans, serum Cu progressively rises and at late stages of infection, liver Cu rises, while kidney Cu declines. The basis for these changes in Cu homeostasis was poorly understood. We report here that the progressive rise in serum Cu is attributable to liver production of the multicopper oxidase ceruloplasmin (Cp). Through studies using Cp-/- mice, we find this elevated Cp helps recover serum Fe levels at late stages of infection, consistent with a role for Cp in loading transferrin with Fe. Cp also accounts for the elevation in liver Cu seen during infection, but not for the fluctuations in kidney Cu. The Cu exporting ATPase ATP7B is one candidate for kidney Cu control, but we find no change in the pattern of kidney Cu loss during infection of Atp7b-/- mice, implying alternative mechanisms. To test whether fungal infiltration of kidney tissue was required for kidney Cu loss, we explored other paradigms of infection. Infection with the intravascular malaria parasite Plasmodium berghei caused a rise in serum Cu and decrease in kidney Cu similar to that seen with C. albicans. Thus, dynamics in kidney Cu homeostasis appear to be a common feature among vastly different infection paradigms. The implications for such Cu homeostasis control in immunity are discussed.
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