ArticlePerspectives on behavior science2019
Using an Experimental Medicine Approach to Identify Novel Determinants of Addiction.
Article in Perspectives on behavior science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Future thinking to decrease real-world drinking in alcohol use disorder: Repairing reinforcer pathology in a randomized proof-of-concept trial.Experimental and clinical psychopharmacology · 2022Trial
- Applying the reinforcer pathology model to alcohol use and suicide risk: An initial test.Journal of the experimental analysis of behavior · 2026Article
- Psychotherapy research for compulsive buying-shopping disorder: Quo vadis?Addictive behaviors reports · 2025Article
- The phenotype of recovery XII: A reinforcer pathology perspective on associations between delay discounting and pain catastrophizing in substance use disorder recovery.Journal of substance use and addiction treatment · 2025Article
- Loss aversion predicts cigarette smoking status across levels of sociodemographic characteristics.Experimental and clinical psychopharmacology · 2024Article
- The Phenotype of Recovery X: Associations between delay discounting, regulatory flexibility, and remission from substance use disorder.Journal of substance use and addiction treatment · 2023Article
- Loss aversion and risk for cigarette smoking and other substance use.Drug and alcohol dependence · 2022Article
- Single case designs for early phase behavioral translational research in health psychology.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2021Article
- Reinforcer pathology's alternative reinforcer hypothesis: A preliminary examination.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2021Article
- Reinforcer pathology in cocaine use disorder: Temporal window determines cocaine valuation.Drug and alcohol dependence · 2021Article
- A Reinforcer Pathology perspective on relapse.Journal of the experimental analysis of behavior · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Our understanding and effectiveness in treating addiction is not fully adequate. Therefore, perhaps developing a pragmatic theory for identifying novel determinants and potential interventions is needed. The experimental medicine approach, derived from Claude Bernard, proposes a methodology for inductive theory development and suggests interventions directed at targets closely aligned with the underlying mechanisms of the disorder. The steps of theory development under this approach are intended to (1) identify an intervention target; (2) develop assays to verify target measurement; (3) engage the target via experiment or intervention; and (4) test the degree to which target engagement produces other therapeutically useful changes in the disorder. In this article, we review these steps in detail using an example from our work. That is, shortened temporal windows (target) is frequently observed among those who are addicted. Delay discounting is an assay used to measure that target. We and others have demonstrated manipulation of the target, delay discounting, is associated with changing the drug valuation among those with addiction. We conclude with a culmination of the experimental medicine approach by proposing a recently developed hypothesis of substance use disorder, Reinforcer Pathology 2.0.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.