ArticleWorld journal of clinical oncology2020
Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review.
Article in World journal of clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Clinical Utility of Molecular Testing in Ameloblastoma: A Systematic Review with Functional Meta-synthesis and Exploratory Meta-analysis.Head and neck pathology · 2026Pooled it
- Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours.Head and neck pathology · 2022Pooled it
- Comparative Analysis Between Dentinogenic Ghost Cell Tumor and Ghost Cell Odontogenic Carcinoma: A Systematic Review.Head and neck pathology · 2021Pooled it
- Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature.Frontiers in oral health · 2021Pooled it
- BRAF and RAS mutations in Vietnamese patients with ameloblastoma.BMC oral health · 2026Article
- Development and validation of a nomogram for predicting recurrence risk in pediatric ameloblastoma treated with conservative surgery.BMC oral health · 2026Article
- Molecular-targeted therapy in ameloblastoma: a systematic review.Archives of craniofacial surgery · 2025Article
- Salivary biomarkers: a promising approach for predicting immunotherapy response in head and neck cancers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
- Ameloblastic Carcinoma: A 40-Year Scoping Review of the Literature.Current issues in molecular biology · 2025Review
- Spotlight on amino acid changing mutations in the JAK-STAT pathway: from disease-specific mutation to general mutation databases.Scientific reports · 2025Article
- Surgical management of mandibular ameloblastoma and immediate reconstruction with iliac crest and costochondrial bone grafts: A case report.International journal of surgery case reports · 2024Article
- Review
- Prognostic value of the expression and localization of cell proliferation and apoptosis markers in unicystic ameloblastomas.Scientific reports · 2024Article
- Review
- Machine learning-based radiomics for predicting BRAF-V600E mutations in ameloblastoma.Frontiers in immunology · 2023Article
- Conventional Ameloblastoma. A Case Report with Microarray and Bioinformatic Analysis.Diagnostics (Basel, Switzerland) · 2022Article
- Brain Tumor Characterization Using Radiogenomics in Artificial Intelligence Framework.Cancers · 2022Review
- Molecular diagnostics in odontogenic tumors.Pathologie (Heidelberg, Germany) · 2022Review
- Ameloblastoma: Retrospective Study and Analysis of 102 Cases Over 10 Years, Single Centre, Institutional Experience.Journal of maxillofacial and oral surgery · 2022Article
- Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis.International journal of oral science · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmeloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies. Different signaling pathways that participate in the progression of these tumors have been identified. B-raf proto-oncogene serine/threonine kinase (BRAF) is a protein involved in the behavior of ameloblastomas, and it is related to many cell mechanisms. BRAF gene mutations have been identified in ameloblastomas, of which the BRAF V600E (valine substituted by glutamic acid at amino acid 600) mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior. Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.
aimTo document the presence of BRAF V600E and additional mutations, their behavior, and targeted therapies in these tumors.
methodsAn electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE, Cochrane, EMBASE, and SpringerLink using the terms "ameloblastomas", "BRAF V600E", "additional mutations", and "targeted therapies". Ameloblastomas were classified according to WHO guidelines. Inclusion criteria were articles in English, published not more than 10 years ago, and studies with laboratory works related to BRAF V600E. Articles were evaluated by two independent reviewers and retrieved for full-text evaluation. The EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible studies. Descriptive statistical analysis was performed.
resultsTwo independent reviewers, with a substantial concordance indicated by a kappa coefficient of
conclusionThe identification of BRAF V600E and additional mutations as an aid in targeted therapies has been a breakthrough in alternative treatments of ameloblastomas where surgical treatments are contraindicated.
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