ArticlePeerJ2020
New insights into human hair: SAXS, SEM, TEM and EDX for Alopecia Areata investigations.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Achieving Highly Efficient Repeatable Hair Perming by Bunte Salt-Thiol Exchange Reaction.ACS omega · 2026Article
- Prevention of Hair Heat Damage via Thermoresponsive Organic Silicon-Modified Keratin.Molecules (Basel, Switzerland) · 2026Article
- Human hair as a diagnostic tool in medicine.Biochemistry and biophysics reports · 2025Review
- Controlled Silver Nanoparticle Formation in Hair Fibers Dyed withMolecules (Basel, Switzerland) · 2025Article
- Quantifying the effects of repeated dyeing: Morphological, mechanical, and chemical changes in human hair fibers.Heliyon · 2024Article
- A Prospective Study of Dermoscopic and Ultrastructural Features of Vitiligo-Associated Leukotrichia.Clinical, cosmetic and investigational dermatology · 2023Article
- The First Evidence of Bacterial Foci in the Hair Part and Dermal Papilla of Scalp Hair Follicles: A Pilot Comparative Study in Alopecia Areata.International journal of molecular sciences · 2022Article
- Magnesium-A Potential Key Player in Inflammatory Bowel Diseases?Nutrients · 2022Article
- Hair EDX Analysis-A Promising Tool for Micronutrient Status Evaluation of Patients with IBD?Nutrients · 2021Article
- Melanins as Sustainable Resources for Advanced Biotechnological Applications.Global challenges (Hoboken, NJ) · 2021Review
- Smart Supra- and Macro-Molecular Tools for Biomedical Applications.Materials (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlopecia areata (AA) is a T-cell-mediated autoimmune disease and affects up to 2% of the population. There is a need for a more profound and rigorous understanding of the structure and composition of human hair affected by AA in order to manage this disease. The aim of this article is to understand the effects of AA on the structure and composition of human hair.
methodsSeveral physico-chemical investigation methods, such as Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy-Dispersive X-ray Spectroscopy (EDX), and microbeam Small Angle X-ray Scattering (SAXS), were used to analyze human hair samples obtained from healthy donors and patients with AA.
resultsSEM revealed more severe hair surface defects for the white regrown hair (W-AA) samples. TEM showed the presence of air-like vesicles located in the endocuticle of regrown hair. Analysis of ultrathin sections of W-AA showed the existence of empty vesicles and smaller melanin granules compared to control samples. SAXS demonstrated that unaffected hair of patients with AA (B-AA) and W-AA melanin aggregates are different in their sizes and shapes compared to the control samples. EDX data showed that W-AA elemental composition was significantly different from the other sample groups. Our study showcases promising non-invasive techniques for a better and more accurate understanding of changes in the internal structure and composition of hair affected by AA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.