Evidence map›Paper›PMID 31976015›Full record

ArticleBeilstein journal of organic chemistry2020

Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos.

Sergii Afonin, Oleg Babii, Aline Reuter, Volker Middel, Masanari Takamiya, Uwe Strähle, Igor V Komarov, Anne S Ulrich

Open access · diamondAbstract read
In one paragraph

Article in Beilstein journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Journal of the American Chemical Society · 2022
    Article
  4. Molecular photoswitches in aqueous environments.Chemical Society reviews · 2021
    Review
  5. Article
  6. Review
  7. Review
  8. Frontiers in chemistry · 2021
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sergii AfoninInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-2356-4226
Oleg BabiiInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany.ORCID https://orcid.org/0000-0001-7107-1402
Aline ReuterInstitute of Organic Chemistry (IOC), KIT, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
Volker MiddelInstitute of Toxicology and Genetics (ITG), KIT, POB 3640, 76021 Karlsruhe, Germany.
Masanari TakamiyaInstitute of Toxicology and Genetics (ITG), KIT, POB 3640, 76021 Karlsruhe, Germany.ORCID https://orcid.org/0000-0002-6524-5813
Uwe SträhleInstitute of Toxicology and Genetics (ITG), KIT, POB 3640, 76021 Karlsruhe, Germany.
Igor V KomarovTaras Shevchenko National University of Kyiv, vul. Volodymyrska 60, 1601 Kyiv, Ukraine.ORCID https://orcid.org/0000-0002-7908-9145
Anne S UlrichInstitute of Biological Interfaces (IBG-2), Karlsruhe Institute of Technology (KIT), POB 3640, 76021 Karlsruhe, Germany.ORCID https://orcid.org/0000-0001-5571-9483
Karlsruhe Institute of Technology · DETaras Shevchenko National University of Kyiv · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluates the embryotoxicity of dithienylethene-modified peptides upon photoswitching, using 19 analogues based on the β-hairpin scaffold of the natural membranolytic peptide gramicidin S. We established an in vivo assay in two variations (with ex vivo and in situ photoisomerization), using larvae of the model organism

Indexed as

diarylethene photoswitchgramicidin Smembrane-active peptidesphotopharmacologyzebrafish embryotoxicity model

Identifiers

PMID31976015
PMCPMC6964649
OpenAlexW3000592553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.