ArticleFocus (American Psychiatric Publishing)2016
Evidence-Based Applications of Combination Psychotherapy and Pharmacotherapy for Depression.
Article in Focus (American Psychiatric Publishing), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Individual Patient Data Network Analysis of the Residual Symptom Structure Following Cognitive-Behavioral Therapy and Escitalopram, Mirtazapine and Venlafaxine for Depression.Frontiers in psychiatry · 2022Pooled it
- Benefits of Sequentially Adding Cognitive-Behavioral Therapy or Antidepressant Medication for Adults With Nonremitting Depression.The American journal of psychiatry · 2019Trial
- Functional Connectivity of the Subcallosal Cingulate Cortex And Differential Outcomes to Treatment With Cognitive-Behavioral Therapy or Antidepressant Medication for Major Depressive Disorder.The American journal of psychiatry · 2017Trial
- A survey of perceived attitudes toward psychotherapy among Thai psychiatrists.BMC psychiatry · 2026Article
- Antidepressant drug use in Europe: past consumption, prescribing patterns and forecast until 2030.International journal of clinical pharmacy · 2026Article
- Trajectories of antidepressant dispensing among privately insured transgender people in the United States.Scientific reports · 2026Article
- Impact of Inflammation on White Matter Integrity and Functional Connectivity in Chronic Major Depressive Disorder.Biological psychiatry · 2026Article
- Assessment of Anti-depressant-Induced Self-Reported Adverse Drug Reactions Among Patients in a Tertiary Care Hospital in Nepal: A Cross-Sectional Study.Drugs - real world outcomes · 2026Article
- Psychotherapy for older adults with depression: a narrative review.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Patient preferences for the integration of exercise for depression into mental health care.Translational behavioral medicine · 2026Article
- Co-Administration Treatment in Drug-Naïve Major Depression: Exploratory Real-World Patterns and Predictors in China.Neuropsychiatric disease and treatment · 2026Article
- Impact of Vitamin D Status and Supplementation on Brain-Derived Neurotrophic Factor and Mood-Cognitive Outcomes: A Structured Narrative Review.Nutrients · 2025Review
- Integrating Dialectical Behaviour Therapy Into the Treatment of Adolescent Depression: A Retrospective Study.Actas espanolas de psiquiatria · 2025Article
- Chronic, combinatorial targeting of NMDARs and 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Psychosocial Interventions for Mental Health Problems of In-patients in Non-psychiatry Units of Selected Tertiary Hospitals in the Philippines: A Mixed-Methods Approach.Acta medica Philippina · 2025Article
- Innovating through tradition: kava-Frontiers in psychology · 2025Review
- Review
- Pharmacotherapy and psychotherapy in depression - complementarity or exclusion?Postepy psychiatrii neurologii · 2024Article
- Somatization in Polypharmacy: Hiding in Plain Sight.Innovations in pharmacy · 2024Article
- Functional connectomics in depression: insights into therapies.Trends in cognitive sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Combination treatment with psychotherapy and antidepressant medication can be provided from the initiation of treatment, sequentially after nonremission with a single-modality treatment or sequentially after remission to buttress the patient's recovery to prevent recurrence. Combination treatment from the initiation of care is best reserved for patients with high depression severity. Sequential addition of treatments, particularly psychotherapy after nonremission to antidepressant medication, is the best supported method of combination, improving remission rates and reducing relapse and recurrence in the long term. However, uncertainty persists around the optimal form of psychotherapy to combine with antidepressant medication for maximizing long-term gains. Better outcomes from combination treatment have been strongest in clinical trials that limited pharmacotherapy to a single antidepressant; benefits of combination treatment have been substantially smaller in trials that allowed flexible use of multiple antidepressant classes. Patients with recurrent major depressive disorder who benefit from combination treatment have better long-term outcomes if an active treatment component is maintained during recovery.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.